 rotate(10)'/%3E%3Cpath d='M.038.113v.15l.15.088.15-.088v-.15L.188.025l-.15.088Z' stroke='%23c44900' stroke-width='.0375' transform='rotate(10)'/%3E%3C/svg%3E)
NAME: Claudia Cristina Biguetti
CREDENTIALS: DDS, MSc, PhD
EMAIL: claudia.biguetti@utrgv.edu
OFFICE PHONE: 956-296-2031
PRIMARY ACADEMIC TITLE: Assistant Professor of Medicine
Dr. Claudia Biguetti is an Assistant Professor at UTRGV and Principal Investigator of the Research Lab of Regenerative Medicine. Her research focuses on immunomodulatory mechanisms in tissue healing and biomaterial integration. She has received funding from UTRGV internal grants, the UT System – Rising Stars, and the NIH, and has authored over 60 peer-reviewed articles and two book chapters.
- Mechanisms of Tissue Healing and Regeneration
- Immunomodulation of biomaterials and osseointegration
- Inflammatory Tissue Destruction
Elvin P, Sanchez A, Reyes AA, Andrade H, Karami M, Mir HT, La Fontaine J, Rodrigues DC, Biguetti C. Foot and ankle biomaterials: a comprehensive review of current applications, challenges, and future directions. J Orthop Transl. 2026 Mar;57:101051. doi: 10.1016/j.jot.2026.101051.
Chandrashekar BL, Arteaga A, Rios E, Mora J, Garlet GP, Rodrigues DC, Biguetti CC. Single local injection of 3S-HMGB1 enhances early bone healing and titanium implant osseointegration in type 2 diabetic mice. J Appl Oral Sci. 2025 Oct 27;33:e20250358. doi: 10.1590/1678-7757-2025-0358. PMID: 41172483.
Primous NR, Elvin PT, Carter KV, Andrade HL, La Fontaine J, Shibuya N, Biguetti CC. Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review. J Clin Med. 2024 Feb 21;13(5):1221. doi: 10.3390/jcm13051221.
Other publications or preprints as first author:
- Biguetti CC, Chaves-Neto AH, Elvin P, La Fontaine J, Brown EL, Hanis CL, Fakhouri WD. Immunological Signatures During Type 2 Diabetes Development and Progression among Mexican Americans in Starr County, Texas. bioRxiv. 2025 Jun 24. doi: 10.1101/2025.06.23.25329883.
- Biguetti CC, Arteaga A, Chandrashekar BL, Rios E, Margolis R, Rodrigues DC. A Model of Immediate Implant Placement to Evaluate Early Osseointegration in 129/Sv Diabetic Mice. Int J Oral Maxillofac Implants. 2023 Dec 12;38(6):1200-1210. doi: 10.11607/jomi.10335. PMID: 38085752.
- Biguetti CC, Lakkasetter Chandrashekar B, Simionato GB, Momesso NR, Duarte MAH, Rodrigues DC, Matsumoto MA. Influence of age and gender on alveolar bone healing post tooth extraction in 129 Sv mice: a microtomographic, histological, and biochemical characterization. Clin Oral Investig. 2023. doi: 10.1007/s00784-023-05087-y.
- Biguetti CC, Cavalla F, Fonseca AC, Tabanez AP, Siddiqui DA, Wheelis S, Taga R, Fakhouri WD, Silva RM, Rodrigues DC, Garlet GP. Effects of Titanium Corrosion Products on In Vivo Biological Response: A Basis for the Understanding of Osseointegration Failures Mechanisms. Frontiers in Materials. 2021. doi:10.3389/fmats.2021.651970
- Biguetti CC*, Couto MC, Silva AC, Shindo JV, Rosa VM, Shinohara AL, Andreo JC, Duarte MA, Wang Z, Brotto MP, Matsumoto MA. New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse. 2020. Front. Endocrinol.doi: 10.3389/fendo.2020.00484. *Corresponding author
- Biguetti CC,Marrelli M, Brotto M. Primum non nocere – Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19)? Rev. Saúde Pública. 2020 doi:10.11606/s1518-8787.2020054002631
- Biguetti CC, De Oliva AH, Healy K, Mahmoud RH, Custódio IC, Constantino DH, Ervolino E, Duarte MAH ;Fakhouri WD, Matsumoto MA. Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological, and immunohistochemical characterization. PLoS One, 2019.doi: https://doi.org/10.1371/journal.pone.0214173
- Biguetti CC, Cavalla F, Silveira EV, Tabanez AP, Francisconi CF, Taga R, Campanelli AP, Trombone APF, Rodrigues DC, Garlet GP.HGMB1 and RAGE as Essential Components of Ti Osseointegration Process in Mice.2019.Front Immunol. doi: 10.3389/fimmu.2019.00709.
- Biguetti CC, Vieira AE, Cavalla F, Fonseca AC, Colavite P, Silva RM, Trombone AP, Garlet GP. CCR2 Contributes to F4/80+ Cells Migration Along Intramembranous Bone Healing in Maxilla, but Its Deficiency Does Not Critically Affect the Healing Outcome. Front Immunol, 2018. doi: 10.3389/fimmu.2018.01804.
- Biguetti CC, Cavalla F, Silveira EM, Fonseca AC, Vieira AE, Tabanez A, Rodrigues D, Trombone AP, Garlet GP. Oral implant osseointegration model in C57Bl/6 mice: microtomographic, histological, histomorphometric and molecular characterization. J Appl Oral Sci, 2018. doi: 10.1590/1678-7757-2017-0601
- Biguetti CC, Cavalla F, Tim C, Saraiva, PP, Orcini WA, Holgado LA, Renno, ACM, Matsumoto MA. Bioactive glass-ceramic bone repair associated or not with autogenous bone: a study of organic bone matrix organization in a rabbit critical-sized calvarial model. Clin Oral Investig, 2019. doi: 10.1007/s00784-018-2450-x.