 rotate(10)'/%3E%3Cpath d='M.038.113v.15l.15.088.15-.088v-.15L.188.025l-.15.088Z' stroke='%23c44900' stroke-width='.0375' transform='rotate(10)'/%3E%3C/svg%3E)
NAME: Claudia Cristina Biguetti
CREDENTIALS: DDS, MSc, PhD
EMAIL: claudia.biguetti@utrgv.edu
OFFICE PHONE: 956-296-2031
PRIMARY ACADEMIC TITLE: Assistant Professor of Medicine
Dr. Claudia Biguetti earned her DDS in 2012 and her MS and PhD in osteoimmunology and biomaterials in 2018. She spent eight years working as a clinical adjunct faculty and a researcher in Brazil before moving to the United States in 2020 for postdoctoral research in Biomedical Engineering at UT Dallas. Since 2022, she has been an Assistant Professor at UTRGV and Principal Investigator of the Research Lab of Regenerative Medicine. Dr. Biguetti's research focuses on immunomodulatory mechanisms in bone healing and biomaterial integration. She has received funding from UTRGV internal grants, the UT System - Rising Stars, and the NIH, with ongoing support from these sources. She has authored or co-authored over 55 peer-reviewed scientific articles and two book chapters.
- Mechanisms of Tissue Healing and Regeneration
- Immunomodulation of biomaterials and osseointegration
- Inflammatory Tissue Destruction
- Biguetti CC, Arteaga A, Chandrashekar BL, Rios E, Margolis R, Rodrigues DC. A Model of Immediate Implant Placement to Evaluate Early Osseointegration in 129/Sv Diabetic Mice. Int J Oral Maxillofac Implants. 2023 Dec 12;38(6):1200-1210. doi: 10.11607/jomi.10335. PMID: 38085752.
- Arteaga A, Biguetti CC, Chandrashekar BL, La Fontaine J, Rodrigues DC. Revolutionizing fracture fixation in diabetic and non-diabetic rats: High mobility group box 1-based coating for enhanced osseointegration. Bone, 2023 Dec;177:116917. doi: 10.1016/j.bone.2023.116917. Epub 2023 Sep 20.PMID: 37739297
- Biguetti CC, Lakkasetter Chandrashekar B, Simionato GB, Momesso NR, Duarte MAH, Rodrigues DC, Matsumoto MA. Influence of age and gender on alveolar bone healing post tooth extraction in 129 Sv mice: a microtomographic, histological, and biochemical characterization. Clin Oral Investig. 2023. doi: 10.1007/s00784-023-05087-y.
- Arteaga A, Biguetti CC, Chandrashekar BL, Mora J, Qureshi A, Rios E, La Fontaine J, Rodrigues DC. A Model of Open Reduction Followed by Internal Fixation (ORIF) to Evaluate Osseointegration and Fracture Healing in Diabetic Lewis Rats. J Foot Ankle Surg. 2023;62(5):832-839. doi: 10.1053/j.jfas.2023.04.011. doi: 10.1053/j.jfas.2023.04.011
- Biguetti CC, Cavalla F, Fonseca AC, Tabanez AP, Siddiqui DA, Wheelis S, Taga R, Fakhouri WD, Silva RM, Rodrigues DC, Garlet GP. Effects of Titanium Corrosion Products on In Vivo Biological Response: A Basis for the Understanding of Osseointegration Failures Mechanisms. Frontiers in Materials. 2021. doi:10.3389/fmats.2021.651970
- Biguetti CC*, Couto MC, Silva AC, Shindo JV, Rosa VM, Shinohara AL, Andreo JC, Duarte MA, Wang Z, Brotto MP, Matsumoto MA. New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse. 2020. Front. Endocrinol.doi: 10.3389/fendo.2020.00484. *Corresponding author
- Biguetti CC,Marrelli M, Brotto M. Primum non nocere – Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19)? Rev. Saúde Pública. 2020 doi:10.11606/s1518-8787.2020054002631
- Biguetti CC, De Oliva AH, Healy K, Mahmoud RH, Custódio IC, Constantino DH, Ervolino E, Duarte MAH ;Fakhouri WD, Matsumoto MA. Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological, and immunohistochemical characterization. PLoS One, 2019.doi: https://doi.org/10.1371/journal.pone.0214173
- Biguetti CC, Cavalla F, Silveira EV, Tabanez AP, Francisconi CF, Taga R, Campanelli AP, Trombone APF, Rodrigues DC, Garlet GP.HGMB1 and RAGE as Essential Components of Ti Osseointegration Process in Mice.2019.Front Immunol. doi: 10.3389/fimmu.2019.00709.
- Biguetti CC, Vieira AE, Cavalla F, Fonseca AC, Colavite P, Silva RM, Trombone AP, Garlet GP. CCR2 Contributes to F4/80+ Cells Migration Along Intramembranous Bone Healing in Maxilla, but Its Deficiency Does Not Critically Affect the Healing Outcome. Front Immunol, 2018. doi: 10.3389/fimmu.2018.01804.
- Biguetti CC, Cavalla F, Silveira EM, Fonseca AC, Vieira AE, Tabanez A, Rodrigues D, Trombone AP, Garlet GP. Oral implant osseointegration model in C57Bl/6 mice: microtomographic, histological, histomorphometric and molecular characterization. J Appl Oral Sci, 2018. doi: 10.1590/1678-7757-2017-0601
- Biguetti CC, Cavalla F, Tim C, Saraiva, PP, Orcini WA, Holgado LA, Renno, ACM, Matsumoto MA. Bioactive glass-ceramic bone repair associated or not with autogenous bone: a study of organic bone matrix organization in a rabbit critical-sized calvarial model. Clin Oral Investig, 2019. doi: 10.1007/s00784-018-2450-x.
Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1xmj0MsHE6nAu/bibliography/public/