Reginald Adiele

Faculty Reginald Adiele

NAME: Reginald Adiele

CREDENTIALS: DVM, PhD

EMAIL: reginald.adiele@utrgv.edu

OFFICE PHONE: 956-296-2023

PRIMARY ACADEMIC TITLE: Assistant Professor of Medicine 

Dr. Reginald Adiele, DVM, PhD, is an Assistant Professor of Medicine in the College of Podiatric Medicine, University of Texas Rio Grande Valley. He is a Doctor of Veterinary Medicine (DVM) from the University of Nigeria Nsukka and a Doctor of Philosophy (PhD) in Biomedical Sciences from the Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island (PE, Canada) with a focus on Mitochondrial Toxicology and Physiology. He completed his Postdoctoral Fellowship in Neuroscience and research project in Multiple Sclerosis (MS) as a Canada Institute of Health Research-Training in Health Research Using Synchrotron Techniques (CIHR-THRUST) Fellow at the Cameco Neuroscience Research Center, Saskatoon City Hospital, Department of Biomedical Sciences, College of Medicine, University of Saskatchewan (SK, Canada).

Dr. Adiele held several academic positions including lecturer at the Department of Physiology, College of Medicine, University of Saskatchewan (SK, Canada), Department of Public Health, Concordia University of Edmonton (AB, Canada), Department of Chemistry and Biology, Lakehead University, Thunder Bay (ON, Canada), Department of Physiology, College of Medicine, University of Toronto, Mississauga (ON, Canada), Department of Forensic Sciences, Arizona State University (AZ, USA); Assistant Professor of Neuroscience, Western Veterinary College, University of Saskatchewan (SK, Canada) and Assistant Professor of Medicine at University of Texas Rio Grande Valley.

Dr. Adiele’s research area cuts across toxicology, metabolism (brain metabolism), mitochondrial bioenergetics and neurology (neuroimmunological diseases). His long-term objective is to understand the molecular, biochemical, cellular, mitochondrial dysfunction and metabolic defects in inflammatory, demyelinating, neurodegenerative, diseases of the Central Nervous System (CNS) including Multiple sclerosis (MS), Alzheimer's Disease (AD), Parkinson Disease (PD), and other Brain Disorders, for therapeutic targets using animal models. A multidisciplinary approach including histology, immunohistochemistry, cytometry, genomics, and neuroimaging are utilized in this research domain.

  • Tham M, Adiele RC et al., 2020. Iron heterogeneity in early active multiple sclerosis lesions. Ann Neurol. 2020 Nov 27. doi: 10.1002/ana.25974. Online ahead of print.
  • Gnaiger E, Adiele RC et al., 2020. Mitochondrial Physiology, Bioenerg Commun https doi 10.26124bec2020-0001.v1.
  • Gnaiger E, Adiele RC et al., 2018. Mitochondrial respiratory states and rates. MitoFit Preprint Archives. 2019. doi:10.26124/. www.mitofit.org/index.php/MitoFit_Preprint_Archives.
  • Adiele RC, Adiele CA. Metabolic defects in multiple sclerosis: a review. Mitochondrion. 2019 Jan; 44:7-14. doi: 10.1016/j.mito.2017.12.005. Epub 2017 Dec 13.
  • Popescu BF, Adiele RC et al,. 2017. Pathogenic Implications of Distinct Patterns of Iron and Zinc in Chronic MS Lesions. Acta Neuropathologica 2017,134(1):45-64.
  • Adiele RC, Adiele CA, Mitochondrial regulatory pathways in the pathogenesis of Alzheimer's disease. J Alzheimer’s Dis. 2016 Jul 6;53(4):1257-70. doi: 10.3233/JAD-150967.
  • Adiele RC, Adiele CA, Progressive multifocal leukoencephalopathy. Journal of Multiple Sclerosis 2014, 1:2 http://dx.doi.org/10.4172/jmso.1000118.
  • Robinson CA, Adiele RC et al., Early and widespread injury of astrocytes in the absence of demyelination in acute hemorrhagic leukoencephalitis. Acta Neuropathologica Communications 2014, 2:52.
  • Adiele RC et al. Differential inhibition of electron transport chain complexes by cadmium and calcium in isolated rainbow trout hepatic mitochondria. Toxicol. Sci. 2012, 127, 110- 119.
  • Adiele RC et al. Features of cadmium and calcium uptake and toxicity in rainbow trout mitochondria. Toxicol. in Vitro 2012, 26, 164-173.
  • Adiele RC et al. Cadmium- and calcium-mediated toxicity in rainbow trout in vivo: interactions on fitness and mitochondrial endpoints. Chemosphere 2011, 85, 1604-1613.
  • Adiele RC et al. Reciprocal enhancement of uptake and toxicity of cadmium and calcium in rainbow trout liver mitochondria. Aquat. Toxicol. 2010, 96, 319-327.
  • Adiele LC, Adiele RC, Enye JC. Wound healing effect of methanol leaf extract of
    Napoleona vogelii (Family: Lecythidaceae) in rats. APJTM 2014, 7, 620-624.
  • Adiele RC et al. Anthelmintic activity of Securidaca longepedunculata root extract in mice: in vitro and in vivo. APJTM, 2013, 6, 841-846.