Eloi Camprubi-Casas, Ph.D.
Eloi Camprubi-Casas, Ph.D.
Assistant Professor of Astrobiochemistry
Office: ESCNE 4.612
Lab: ESCNE 4.513
956-665-2950
eloi.camprubicasas@utrgv.edu
Google Scholar profile: https://scholar.google.co.uk/citations?user=AkY_lKcAAAAJ&hl=en
ORCID 0000-0001-9339-9062 (active link: https://orcid.org/0000-0001-9339-9062)
Courses
CHEM 4306 Special Topics in Biochemistry: Astrobiology
Education
Ph.D. in Chemistry, University College London, United Kingdom (2018)
M. Res. in Structural and Molecular Biology, University College London, UK (2014)
B.S. in Biochemistry, Universitat Autonoma de Barcelona, Spain (2012)
B.S. in Biology, Universitat Autonoma de Barcelona, Spain (2011)
Scientific Appointments
Sep 22 – Present: Assistant Professor of Astrobiochemistry, UTRGV, Edinburg (TX), US
Oct 21 – Jul 22: Fellow of the Human Frontier Science Program, Earth-Life Science Institute, Tokyo, Japan
May 18 – Sep 21: Fellow of the Origins Center, Utrecht University, Utrecht, The Netherlands
Areas of Interest
Origin of life, astrobiology, biosignatures, Ocean Worlds, hydrothermal systems, origins of evolution, early Earth climate and dynamics, planetary chemistry, space exploration
Research
Hear Dr. Camprubi talk about his research on the Origin of Life on YouTube: https://www.youtube.com/watch?v=ssy_lF120Pw
My work focuses on probing the transition between geochemistry and biochemistry, on understanding the laws of living systems, on chemical biosignatures for space exploration, and on studying biological traits emerging in autocatalytic (self-producing) chemical systems.
Prebiotic Chemistry: I am interested in understanding under which conditions certain abiotic chemistry transitions into a living system. I have focused on the non-enzymatic synthesis of sugars (necessary for the synthesis of nucleotides), on studying the synthesis and properties of P-bearing organics, and on the interactions (positive and negative) between these pathways. Moving away from synthesis, I am fascinated by prebiotic coupling systems which allow for non-spontaneous processes to occur by linking them to spontaneous ones. These systems are crucial to modern (and ancient) life, and we have all the reasons to think they had an important role in its emergence.
Hydrothermal Systems: Hydrothermal systems are very prevalent on Earth and other silicate-rich planetary bodies. Rock-water interactions generate a reactivity landscape replete with simple inorganics and ample free energy. We use high-pressure microfluidics reactors which let us simulate these out-of-equilibrium settings with precision in the lab. We often use minerals as catalysts drawing inspiration from the plethora of metallic cofactors prevalent in biology. We can either prepare thin mineral sheets under controlled conditions before an experiment or allow for their spontaneous precipitation during its course.
Biosignatures and Space Exploration: Being able to study extraterrestrial life would be immeasurably useful for us to understand life beyond the contingencies of life on Earth. Deciding which celestial bodies should be prioritized for this endeavor is always contentious. I want to know which extraterrestrial chemicals are indicative of an alien biosphere (i.e. are biosignatures). I am interested in profiling the geochemistry of planetary bodies beyond Earth, particularly that of Ocean Worlds where hydrothermal systems are widespread. We are now building the Boreas Simulator – named after the Greek god of winter – to study how hydrothermally-synthesized organics at Enceladus become altered by the low-pressure, low-temperature, and high-irradiation conditions in its icy surface.
Origins of Darwinian Evolution: Information polymers (RNA, DNA) serve as information repositories in modern and ancient cells. It is possible this was not the case during the early steps in the transition from geo- to biochemistry. Composomes are molecular assemblies whose composition is information. Vesicles are made of amphiphilic molecules and could have operated as composomes, with their constituent parts governing their stability and fitness (capability to replicate). Whether vesicles display significant enough levels of heredity between subsequent reproductive cycles will determine whether such composomes are capable of evolution. It’s likely the key lies in understanding the interaction between the biophysics of vesicle replication and the dynamics of autocatalytic networks producing vesicle monomers.
Recent Publications (h-index 7; citations 707)
*Indicates a supervised student as co-author
(2023) Kopacz, N.*, Corazzi, M. A., Poggiali, G., von Essen, A., Kofman, V., Fornaro, T., van Ingen, H., Camprubi, E., King H. E., Brucato, J. R., ten Kate, I. L. The photochemical evolution of polycyclic aromatic hydrocarbons and nontronite clay on early Earth and Mars. Icarus, 394:115437
(2022) Camprubi, E., Muchowska, K. B., ten Kate, I. L., Markovitch, O., Otto, S. Prebiotic Chemistry: From dust to molecules and beyond. Chapter 2 in New Frontiers in Astrobiology, Elsevier Cambridge, 19-47
(2022) Camprubi, E., Harrison, S. A., Jordan, S. F., Bonnel, J.*, Pinna, S., Lane, N. Do soluble phosphates direct the formose reaction towards pentose sugars? Astrobiology, 22(3):981-991
(2022) Giese, C.C.*, ten Kate, I.L., van den Ende, M.P.A., Wolthers, M., Aponte, J., Camprubi, E., Dworkin, J., Elsila, J.E., Hangx, S., King, H.E., Mclain, H.L., Plümper, P., Tielens, A.G.G.M. Experimental and theoretical constraints on amino acid formation from PAHs in asteroidal settings. ACS Earth and Space Chemistry, 6(3):468-481
(2021) Živković, A., Somers, M.*, Camprubi, E., King, H. E., Wolthers, M., de Leeuw, N. H. Changes in CO2 adsorption affinity related to Ni doping in FeS surfaces: A DFT-D3 study. Catalysts, 11(486)
(2020) Preiner, M., Asche, S., Becker, S., Betts, H., Boniface, A., Camprubi, E., Chandru, K., Erastova, V., Garg, S., Khawaja, N., Kostyrka, G., Machne, R., Moggioli, G., Muchowska, K. B., Neukirchen, S., Peter, B., Pichlhöfer, E., Radványi, A., Ring, C., Rossetto, D., Salditt, A., Schmelling, N. M., Sousa, F., Tria, F., Vörös, D., Xavier, J. C. The future of origin of life research: bridging decades-old divisions. Life, 10:3
(2020) Taubner, R. S., Olsson-Francis, K., Vance, S., Antunes, A., Barge, L., Bollengier, O., Brown, M. J., Camprubi, E., de Vera, J. P., Goodman, J., Hand, K., Jebbar, M., Journaux, B., Karatekin, Ö., Klenner, F., Noack, L., Postberg, F., Rabbow, E., Ramkinsson, N., Rettberg, P., Rückriemen-Bez, T., Sekine, Y., Shibuya, T., Soderlund, K. Experimental and simulation efforts in the astrobiological exploration of exooceans. Space Science Reviews, 216:9
(2019) Camprubi, E., de Leeuw, J. W., House, C. H., Raulin, F., Russell, M. J., Spang, A., Tirumalai, M. R., Westall, F. The emergence of life. Space Science Reviews, 215:56 (also appearing as a chapter in Ocean Worlds: Habitability in the Outer Solar System and Beyond, Springer, 2021)
(2019) Choblet, G., Cadek, O., Freissinet, C., Jones, G., Le Gall, A., MacKenzie, S., Neveu, M., Olsson-Francis, K., Saur, J., Schmidt, J., Sekine, Y., Tobie, G., Vance, S., Barge, L., Behounkova, M., Buch, A., Camprubi, E., Hedman, M., Lainey, V., Lucchetti, A., Mitri, G., Nimmo, F., Panning, M., Postberg, F., Shibuya, T., Sotin, C., Soucek, O., Szopa, C., Tomohiro, U., Van Hoolst, T. Enceladus as a potential oasis for life: Science goals and investigations for future explorations (a white paper submitted in response to ESA’s Voyage 2050 call). Published also in Experimental Astronomy, https://doi.org/10.1007/s10686-021-09808-7
(2018) Camprubi, E., Whicher, A., Pinna, S.*, Herschy, B., Lane, N. Acetyl phosphate as a primordial energy currency at the origin of life. Origin of life and evolution of biospheres, 48(2):159-179
(2017) Camprubi, E., Jordan, S., Vasiliadou, R., Lane, N. Iron catalysis at the origin of life. IUBMB Life, 69(6), 373-381
(2016) Sojo, V., Herschy, B., Whicher, A., Camprubi, E., Lane, N. The origin of life in alkaline hydrothermal vents. Astrobiology, 16(2), 181-197
(2014) Herschy, B., Whicher, A., Camprubi, E., Watson, C., Dartnell, L., Ward, J., Evans, J. R. G., Lane, N. An Origin-of-Life reactor to simulate alkaline hydrothermal vents. Journal of Molecular Evolution, 79, 213-227
Other Activities
I am very active in science service and dissemination activities, such as providing peer-reviewing expertise for scientific journals (including Nature, PNAS, and Earth and Planetary Science Letters), topic- (Symmetry, ISSN: 2073-8994) and guest-editing (Life, ISSN: 2075-1729) for peer-reviewed scientific journals, organizing and attending scientific conferences, and acting as a member of several interdisciplinary institutions.
I believe that engaging the public is our responsibility as scientists given that, in many cases, our funding is derived from public sources. This is particularly important for all basic disciplines, but also for applied ones – such as the space sciences – whose long-term benefits are often difficult to grasp for a general audience. Please, reach out if you would like to collaborate on science divulgation activities.