Mohammed Farooqui

Mohammed Farooqui, Ph.D.

Office Hours

Courses

BIOL 4416 Enviromental Toxicology
BIOL 3405 Histology

Education

Ph.D. University of Illinois. 1979
M.S. University of Illinois. 1975
M.Sc. Andhra Pradesh Agricultural University. Hyderabad, India. 1970.
B.Sc. Andhra Pradesh Agricultural University. 196
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Areas of Interest

Toxicology, aliphatic nitriles, pesticides, pharmacokinetics, GSH, cyanide.

Research

Our current research involves effect of common beverages such as coffee products and alcohol on the toxicity and metabolism of aliphatic nitriles. In general my interest focuses on various toxic aspects of environmental and industrial chemicals on human systems. In more specific terms, we am interested in molecular interactions and metabolism of these chemicals and trying to understand their mechanisms of actions through the studies on various organ systems in laboratory animals. These studies are useful in exploring human health risks.

For about two decades we have been involved in such studies on chemicals including pesticides (DDT and its analogs) in insects and industrial chemicals (acrylonitrile, propionitrile, dimethyl aminopropionitrile, formaldehyde, methacrylonitrile and allynitrile) in laboratory animals including rats and mice. Actual investigations involved the studies on the in vivo and in vitro metabolism, pharmacokinetics in blood and other organ systems, molecular interactions and covalent binding with biomolecules including DNA, RNA, proteins and lipids.

In our studies we have found that the toxicity and other actions of aliphatic nitriles are not entirely due to their ability to generate cyanide ions in biological system as previously believed, but also due to either entire molecule or metabolites other than cyanide. For example many of the nitriles are capable of forming epoxides in vivo and become more potent alkylating agents. Also, these chemicals exploit the glutathione (GSH) pathway. These chemicals form GSH conjugates and result in depletion of GSH which in itself is detrimental to the survival of normal cells.

Most Recent Publications

Curriculum Vitae