Megan Keniry, Ph.D.

Megan Keniry, Ph.D.

Megan Keniry, Ph.D.
Assistant Professor
SCI 2.304
Office: (956) 665-7463
Research Field
megan.keniry@utrgv.edu

Office Hours

Courses

Cell Biology (BIOL 3412)

Education

Ph.D. Biology, University of Oregon, Eugene, Oregon. 2002.
B.S. Biochemistry, State University of New York at Albany, Albany, New York. 1995.

Areas of Interest

Signal transduction, cell cycle, PIKE pathway.

Cellular growth and survival require the systematic coordination of signaling networks that direct gene expression, cell cycle, growth, polarity, motility, metabolism and cellular identity. My laboratory investigates signal transaction events on the phosphatidylinositol  3 kinase (PIKE) pathway with a focus on transcriptional outputs. PI3K has global effects on cellular signal transaction by increasing the concentration of the lipid second messenger phosphatidylinositol 3,4 ,5 trisphosphate (PIP3). This lipid activates proteins that promote cellular growth and survival. The PI3K pathway is almost universally altered in cancer as well as diabetes. In cancer, PI3K output is almost universally increased. The b-ZIP transcription factor NFIL3 was recently discovered as a novel regulator of PI3K transcriptional output in cancer. NFIL3 is highly expressed in poor prognosis cancers and promotes cancer cell survival. Research in my laboratory is focused at delineating how NFIL3 contributes to poor prognosis in cancer by identifying signaling pathways and cellular processes that are impacted by this factor. Current laboratory projects include: (1) Investigating transcriptional outputs of NFIL3 on the PI3K pathway, in cancer and beyond and (2) Examining regulatory mechanisms.


Most Recent Publications

Curriculum Vitae