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News
The Impact of Nf1 Mutation on Oligodendrocyte Development and Fine Motor Learning
Name of PI: Alejandro Lopez-Juarez
Department of PI: BMED
The Impact of Nf1 Mutation on Oligodendrocyte Development and Fine Motor Learning
Purpose: The brain white matter and its characteristic component myelin have emerged as key regulators of brain function, and their disruption potentially contributes to neurological conditions observed in children with Neurofibromatosis type 1 (NF1). Here, myelin-focused mouse genetic models of NF1 will be used to unveil developmental and functional abnormalities of myelinating cells, abnormalities which potentially impact activity and learning in a voluntary learning test. By discovering mechanisms and their precise windows of time, these studies will facilitate the establishment of early preventive or remedial treatments for neurological issues in NF1, based on maintaining, restoring, or improving the function of myelin.
Funding agency: National Institutes of Health
Amount and Award period: Total cost $592,000.00, July 1st, 2024 – May 31st, 2028
Department of PI: BMED
The Impact of Nf1 Mutation on Oligodendrocyte Development and Fine Motor Learning
Purpose: The brain white matter and its characteristic component myelin have emerged as key regulators of brain function, and their disruption potentially contributes to neurological conditions observed in children with Neurofibromatosis type 1 (NF1). Here, myelin-focused mouse genetic models of NF1 will be used to unveil developmental and functional abnormalities of myelinating cells, abnormalities which potentially impact activity and learning in a voluntary learning test. By discovering mechanisms and their precise windows of time, these studies will facilitate the establishment of early preventive or remedial treatments for neurological issues in NF1, based on maintaining, restoring, or improving the function of myelin.
Funding agency: National Institutes of Health
Amount and Award period: Total cost $592,000.00, July 1st, 2024 – May 31st, 2028
Dr. Ruth Crutchfield and Dr. Mengxuan Wu National Awards