John Blangero, Ph.D.

Dr John Blangero performing as the lead vocalist in Harlequin Reborn

Director, Genomics Computing Center

South Texas Diabetes and Obesity Institute

School of Medicine

Office: Brownsville Campus, BROBL, Room 131
1 West University Blvd
Brownsville, TX.  78520
Phone: +1 (956)-882-7522


1986 Ph.D. Population Genetics, Case Western Reserve University, Cleveland, Ohio

1982 M.A. Biological Anthropology, Case Western Reserve University, Cleveland, Ohio

Research Focus

The genetic underpinnings of common diseases like diabetes and heart disease have proven to be complex. Dr. Blangero has focused his research on the development and application of sophisticated statistical methods to analyze the vast quantities of genetic data generated in large family studies. Dr. Blangero is developing novel approaches to integrate bioinformatic data mining, gene expression analysis, epigenomic, metabolomic, functional genomic and association analysis into methods that will significantly reduce the time and cost of gene discovery.

In addition to serving as Director of the STDOI Genomics Computing Center in the UTRGV School of Medicine, Dr. Blangero is the director of the San Antonio Family Heart Study which continues to be an invaluable resource for exploring many genetic questions. His research group is utilizing data generated by this project to search for genes that influence risk of cardiovascular disease and diabetes. He also has a major program searching for genes that regulate brain structure and function. The San Antonio Family Heart Study was one of the first major studies to incorporate genomic imaging--an emerging field that combines genetic analysis with magnetic resonance imaging to obtain highly detailed information on both anatomic variation and function in the heart and in the brain.

Dr. Blangero led the establishment of state-of-the-art molecular genetics laboratories and computing facilities on the UTRGV Brownsville campus and orchestrated the installation of an 11,000-processor high-performance computer cluster named MEDUSA which serves as one of the world's largest parallel computing cluster devoted to genetic research. Dr. Blangero’s group also added new genome sequencers to enable deep sequencing techniques to more quickly find gene variants, measure their output, and accelerate the pace of translational research leading to better diagnostics and eventual treatments for improved human health. Most recently, Dr. Blangero has been involved in the development of a large-scale program for the routine production of stem cells from blood for use in functional genomic studies. His laboratory is pursuing high dimensional phenotyping of different cell types that are derived from such stem cells to better understand the function of human sequence variation.

Dr. Blangero has major multi-year multi-million dollar research grants from the National Institute of Mental Health, the National Institute of Diabetes and Digestive Disorders, and the National Heart Lung and Blood Institute to utilize whole genome sequencing to search for genes influencing psychiatric disorders, diabetes, and cardiovascular disease respectively.

Intramural Appointments


Extramural Appointments

  • Director, Genomics Computing Center, STDOI, UTRGV School of Medicine

  • Interim Director, Neuroscience, UTRGV School of Medicine

  • Member, Strategic Planning Committee, University of Texas Rio Grande Valley

  • Member, Search Committee for Chair, UTRGV School of Medicine Department of Biomedical Sciences

  • Member, Editorial Advisory Board, Genomics and Computational Biology
  • Member, American Diabetes Association Grant Panel

  • Member, NIMH Grant Review Committee for RFA “Gene Networks: Solving the Molecular Puzzle of Psychiatric Disorders”

Recent Publications

  • He KY, Kelly TN, Wang H, Liang J, Zhu L, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bielak LF, Bress AP, Brody JA, Chang YC, Chang YC, de Vries PS, Duggirala R, Fox ER, Franceschini N, Furniss AL, Gao Y, Guo X, Haessler J, Hung YJ, Hwang SJ, Irvin MR, Kalyani RR, Liu CT, Liu C, Martin LW, Montasser ME, Muntner PM, Mwasongwe S, Naseri T, Palmas W, Reupena MS, Rice KM, Sheu WH, Shimbo D, Smith JA, Snively BM, Yanek LR, Zhao W, Blangero J, Boerwinkle E, Chen YI, Correa A, Cupples LA, Curran JE, Fornage M, He J, Hou L, Kaplan RC, Kardia SLR, Kenny EE, Kooperberg C, Lloyd-Jones D, Loos RJF, Mathias RA, McGarvey ST, Mitchell BD, North KE, Peyser PA, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Rotter JI, Taylor KD, Tracy R, Vasan RS; Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Morrison AC, Levy D, Chakravarti A, Arnett DK, Zhu X. Rare coding variants in RCN3 are associated with blood pressure. BMC Genomics. 2022 Feb 19;23(1):148. doi: 10.1186/s12864-022-08356-4.
  • Blackburn NB, Leandro AC, Nahvi N, Devlin MA, Leandro M, Martinez Escobedo I, Peralta JM, George J, Stacy BA, deMaar TW, Blangero J, Keniry M, Curran JE. Transcriptomic profiling of fibropapillomatosis in Green Sea Turtles (Chelonia mydas) from South Texas. Front Immunol. 2021 Feb 24;12:630988. doi: 10.3389/fimmu.2021.630988. eCollection 2021.PMID: 33717164
  • Kochunov P, Zavaliangos-Petropulu A, Jahanshad N, Thompson PM, Ryan MC, Chiappelli J, Chen S, Du X, Hatch K, Adhikari B, Sampath H, Hare S, Kvarta M, Goldwaser E, Yang F, Olvera RL, Fox PT, Curran JE, Blangero J, Glahn DC, Tan Y, Hong LE. A white matter connection of Schizophrenia and Alzheimer's Disease. Schizophr Bull. 2021 Jan 23;47(1):197-206. doi: 10.1093/schbul/sbaa078. PMID: 32681179
  • Koenis MMG, Durnez J, Rodrigue AL, Mathias SR, Alexander-Bloch AF, Barrett JA, Doucet GE, Frangou S, Knowles EEM, Mollon J, Denbow D, Aberizk K, Zatony M, Janssen RJ, Curran JE, Blangero J, Poldrack RA, Pearlson GD, Glahn DC. Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans. Hum Brain Mapp. 2021 Apr 15;42(6):1727-1741. doi: 10.1002/hbm.25324. Epub 2020 Dec 19. PMID: 33340172
  • Blackburn NB, Meikle PJ, Peralta JM, Kumar S, Leandro AC, Bellinger MA, Giles C, Huynh K, Mahaney MC, Göring HHH, VandeBerg JL, Williams-Blangero S, Glahn DC, Duggirala R, Blangero J, Michael LF, Curran JE. Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3. Circ Genom Precis Med. 2021 Jun;14(3):e003232. doi: 10.1161/CIRCGEN.120.003232. Epub 2021 Apr 22.
  • Kwong AM, Blackwell TW, LeFaive J, de Andrade M, Barnard J, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Cade BE, Chasman DI, Chen H, Conomos MP, Cupples LA, Ellinor PT, Eng C, Gao Y, Guo X, Ryan Irvin M, Kelly TN, Kim W, Kooperberg C, Lubitz SA, Mak ACY, Manichaikul AW, Mathias RA, Montasser ME, Montgomery CG, Musani S, Palmer ND, Peloso GM, Qiao D, Reiner AP, Roden DM, Shoemaker MB, Smith JA, Smith NL, Lasky Su J, Tiwari HK, Weeks DE, Weiss ST; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group, Scott LJ, Smith AV, Abecasis GR, Boehnke M, Min Kang H. Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries. Genetics. 2021 Mar 15:iyab044. doi: 10.1093/genetics/iyab044. Online ahead of print.PMID: 33720349 
  • Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Córdova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, García-Ortiz H, Gieger C, Glaser B, González-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jørgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martínez-Hernández A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusié-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY; AMP-T2D-GENES Consortia, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9;12(1):3505. doi: 10.1038/s41467-021-23556-4.
  • Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M, Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet. 2021 May 6;108(5):874-893. doi: 10.1016/j.ajhg.2021.04.003. Epub 2021 Apr 21. Erratum in: Am J Hum Genet. 2021 Jun 3;108(6):1165. PMID: 33887194; PMCID: PMC8206199.
  • Mollon J, Knowles EEM, Mathias SR, Gur R, Peralta JM, Weiner DJ, Robinson EB, Gur RE, Blangero J, Almasy L, Glahn DC.  Genetic influence on cognitive development between childhood and adulthood.  Mol Psychiatry. 2021 Feb;26(2):656-665. doi: 10.1038/s41380-018-0277-0. Epub 2018 Oct 19. PMID: 30644433
  • Morales LD, Cromack DT, Tripathy D, Fourcaudot M, Kumar S, Curran JE, Carless M, Göring HHH, Hu SL, Lopez-Alvarenga JC, Garske KM, Pajukanta P, Small KS, Glastonbury CA, Das SK, Langefeld C, Hanson RL, Hsueh WC, Norton L, Arya R, Mummidi S, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP. Further evidence supporting a potential role for ADH1B in obesity. Sci Rep. 2021 Jan 21;11(1):1932. doi: 10.1038/s41598-020-80563-z.PMID: 33479282 
  • Mummidi S, Farook VS, Reddivari L, Hernandez-Ruiz J, Diaz-Badillo A, Fowler SP, Resendez RG, Akhtar F, Lehman DM, Jenkinson CP, Arya R, Lynch JL, Canas JA, DeFronzo RA, Hale DE, Blangero J, Lopez-Alvarenga JC, Duggirala R, Vanamala JKP. Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children. Sci Rep. 2021 Jan 13;11(1):871. doi: 10.1038/s41598-020-79387-8.PMID: 33441626
  • Sønderby IE, van der Meer D, Moreau C, Kaufmann T, Walters GB, Ellegaard M, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Bøen R, Cahn W, Calhoun VD, Caspers S, Ching CRK, Cichon S, Ciufolini S, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Desrivieres S, Doherty JL, Donohoe G, Draganski B, Ehrlich S, Eising E, Espeseth T, Fejgin K, Fisher SE, Fladby T, Frei O, Frouin V, Fukunaga M, Gareau T, Ge T, Glahn DC, Grabe HJ, Groenewold NA, Gústafsson Ó, Haavik J, Haberg AK, Hall J, Hashimoto R, Hehir-Kwa JY, Hibar DP, Hillegers MHJ, Hoffmann P, Holleran L, Holmes AJ, Homuth G, Hottenga JJ, Hulshoff Pol HE, Ikeda M, Jahanshad N, Jockwitz C, Johansson S, Jönsson EG, Jørgensen NR, Kikuchi M, Knowles EEM, Kumar K, Le Hellard S, Leu C, Linden DEJ, Liu J, Lundervold A, Lundervold AJ, Maillard AM, Martin NG, Martin-Brevet S, Mather KA, Mathias SR, McMahon KL, McRae AF, Medland SE, Meyer-Lindenberg A, Moberget T, Modenato C, Sánchez JM, Morris DW, Mühleisen TW, Murray RM, Nielsen J, Nordvik JE, Nyberg L, Loohuis LMO, Ophoff RA, Owen MJ, Paus T, Pausova Z, Peralta JM, Pike GB, Prieto C, Quinlan EB, Reinbold CS, Marques TR, Rucker JJH, Sachdev PS, Sando SB, Schofield PR, Schork AJ, Schumann G, Shin J, Shumskaya E, Silva AI, Sisodiya SM, Steen VM, Stein DJ, Strike LT, Suzuki IK, Tamnes CK, Teumer A, Thalamuthu A, Tordesillas-Gutiérrez D, Uhlmann A, Ulfarsson MO, van 't Ent D, van den Bree MBM, Vanderhaeghen P, Vassos E, Wen W, Wittfeld K, Wright MJ, Agartz I, Djurovic S, Westlye LT, Stefansson H, Stefansson K, Jacquemont S, Thompson PM, Andreassen OA; ENIGMA-CNV working group. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Transl Psychiatry. 2021 Mar 22;11(1):182. doi: 10.1038/s41398-021-01213-0.PMID: 33753722
  • Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, Köttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O'Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Hernandez RD, O'Connor TD, Abecasis GR. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y. Epub 2021 Feb 10.PMID: 33568819 
  • Kumar S, Curran JE, Kumar K, DeLeon E, Leandro AC, Peralta J, Williams-Blangero S, Blangero J. Disease modeling and disease gene discovery in cardiomyopathies: A molecular study of induced pluripotent stem cell generated cardiomyocytes. Int J Mol Sci. 2021 Mar 24;22(7):3311. doi: 10.3390/ijms22073311.
  • Kumar S, Curran JE, Williams-Blangero S, Blangero J. Efficient generation of functional hepatocytes from human induced pluripotent stem cells for disease modeling and disease gene discovery. Methods Mol Biol. 2021 Mar 27. doi: 10.1007/7651_2021_375. Epub ahead of print
  • Natarajan P, Pampana A, Graham SE, Ruotsalainen SE, Perry JA, de Vries PS, Broome JG, Pirruccello JP, Honigberg MC, Aragam K, Wolford B, Brody JA, Antonacci-Fulton L, Arden M, Aslibekyan S, Assimes TL, Ballantyne CM, Bielak LF, Bis JC, Cade BE, Do R, Doddapaneni H, Emery LS, Hung YJ, Irvin MR, Khan AT, Lange L, Lee J, Lemaitre RN, Martin LW, Metcalf G, Montasser ME, Moon JY, Muzny D, O'Connell JR, Palmer ND, Peralta JM, Peyser PA, Stilp AM, Tsai M, Wang FF, Weeks DE, Yanek LR, Wilson JG, Abecasis G, Arnett DK, Becker LC, Blangero J, Boerwinkle E, Bowden DW, Chang YC, Chen YI, Choi WJ, Correa A, Curran JE, Daly MJ, Dutcher SK, Ellinor PT, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, He J, Hveem K, Jarvik GP, Kaplan RC, Kardia SLR, Kenny E, Kim RW, Kooperberg C, Laurie CC, Lee S, Lloyd-Jones DM, Loos RJF, Lubitz SA, Mathias RA, Martinez KAV, McGarvey ST, Mitchell BD, Nickerson DA, North KE, Palotie A, Park CJ, Psaty BM, Rao DC, Redline S, Reiner AP, Seo D, Seo JS, Smith AV, Tracy RP, Vasan RS, Kathiresan S, Cupples LA, Rotter JI, Morrison AC, Rich SS, Ripatti S, Willer C; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen, Peloso GM. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021 Apr 12;12(1):2182. doi: 10.1038/s41467-021-22339-1.
  • Lopez-Alvarenga JC, Martinez DA, Diaz-Badillo A, Morales LD, Arya R, Jenkinson CP, Curran JE, Lehman DM, Blangero J, Duggirala R, Mummidi S, Martinez RD. Association of HIV-1 infection and antiretroviral therapy with type 2 diabetes in the Hispanic population of the Rio Grande Valley, Texas, USA. Front Med (Lausanne). 2021 Jul 5;8:676979. doi: 10.3389/fmed.2021.676979.
  • Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S. Population sequencing data reveal a compendium of mutational processes in the human germ line. Science. 2021 Aug 27;373(6558):1030-1035. doi: 10.1126/science. aba7408. Epub 2021 Aug 12.
  • Goyal S, Tanigawa Y, Zhang W, Chai JF, Almeida M, Sim X, Lerner M, Chainakul J, Ramiu JG, Seraphin C, Apple B, Vaughan A, Muniu J, Peralta J, Lehman DM, Ralhan S, Wander GS, Singh JR, Mehra NK, Sidorov E, Peyton MD, Blackett PR, Curran JE, Tai ES, van Dam R, Cheng CY, Duggirala R, Blangero J, Chambers JC, Sabanayagam C, Kooner JS, Rivas MA, Aston CE, Sanghera DK.  APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups.  Lipids Health Dis. 2021 Sep 21;20(1):113. doi: 10.1186/s12944-021-01531-8.  PMID: 34548093
  • Knowles EEM, Peralta JM, Almasy L, Nimgaonkar V, McMahon FJ, McIntosh AM, Thomson P, Mathias SR, Gur RC, Curran JE, Raventós H, Contreras J, Jablensky A, Badcock J, Blangero J, Gur RE, Glahn DC.  Genetic overlap profiles of cognitive ability in psychotic and affective illnesses: A multisite study of multiplex pedigrees.  Biol Psychiatry. 2021 Sep 15;90(6):373-384. doi: 10.1016/j.biopsych.2021.03.012. Epub 2021 Mar 17.  PMID: 33975707
  • Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang YC, Chen YI, Cheng CY, Choi WJ, Chowdhury R, Contreras-Cubas C, Córdova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, García-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, Lyssenko V, Ma RCW, Martin LW, Martínez-Hernández A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Mendoza-Caamal E, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macías H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O'Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusié-Luna T, Udler MS, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR; AMP-T2D-GENES, Myocardial Infarction Genetics Consortium; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; NHLBI TOPMed Lipids Working Group, Kathiresan S, Rader DJ, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM.  Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.  Am J Hum Genet. 2022 Jan 6;109(1):81-96. doi: 10.1016/j.ajhg.2021.11.021. Epub 2021 Dec 20.  PMID: 34932938
  • Alexander-Bloch AF, Raznahan A, Vandekar SN, Seidlitz J, Lu Z, Matthias SR, Knowles E, Mollon J, Rodrigue A, Curran JE, Görring HHH, Satterthwaite TD, Gur RE, Bassett DS, Hoftman GD, Pearlson G, Shinohara RT, Liu S, Fox PT, Almasy L, Blangero J, Glahn DC. Imaging local genetic influences on cortical folding. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7430-7436. doi: 10.1073/pnas.1912064117. Epub 2020 Mar 13. PMID: 32170019
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  • Blackburn NB, Michael LF, Meikle PJ, Peralta JM, Mosior M, McAhren S, Bui HH, Bellinger MA, Giles C, Kumar S, Leandro AC, Almeida M, Weir JM, Mahaney MC, Dyer TD, Almasy L, VandeBerg JL, Williams-Blangero S, Glahn DC, Duggirala R, Kowala M, Blangero J, Curran JE. Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway. J Lipid Res. 2019 Sep;60(9):1630-1639. doi: 10.1194/jlr. P094433. Epub 2019 Jun 21. PMID:31227640
  • Caballero M, Seidman DN, Qiao Y, Sannerud J, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Carmi S, Williams AL. Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives. PLoS Genet. 2019 Dec 20;15(12): e1007979. doi: 10.1371/journal.pgen.1007979. eCollection 2019 Dec. PMID: 31860654
  • Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology and Hemostasis Working Group, Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X. Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole-genome sequencing studies. Am J Hum Genet. 2019 Feb 7;104(2):260-274. doi: 10.1016/j.ajhg.2018.12.012. Epub 2019 Jan 10. PMID: 30639324
  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Córdova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, García-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jørgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martínez-Hernández A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C; Broad Genomics Platform, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberón X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusié-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun;570(7759):71-76. doi: 10.1038/s41586-019-1231-2. Epub 2019 May 22. PMID: 31118516
  • Glahn DC, Nimgaonkar VL, Raventós H, Contreras J, McIntosh AM, Thomson PA, Jablensky A, McCarthy NS, Charlesworth JC, Blackburn NB, Peralta JM, Knowles EEM, Mathias SR, Ament SA, McMahon FJ, Gur RC, Bucan M, Curran JE, Almasy L, Gur RE, Blangero J. Rediscovering the value of families for psychiatric genetics research. Mol Psychiatry. 2019 Apr;24(4):523-535. doi: 10.1038/s41380-018-0073-x. Epub 2018 Jun 28.
  • Johnson MP, Keyho R, Blackburn NB, Laston S, Kumar S, Peralta J, Thapa SS, Towne B, Subedi J, Blangero J, Williams-Blangero S. Glycated serum protein genetics and pleiotropy with cardiometabolic risk factors. J Diabetes Res. 2019 Apr 4;2019:2310235. doi: 10.1155/2019/2310235. eCollection 2019. PMID: 31089471
  • Knowles EEM, Curran JE, Goring HHH, Mathias SR, Mollon J, Rodrigue A, Olvera RL, Leandro A, Duggirala R, Almasy L, Blangero J, Glahn DC. Family-based analyses reveal novel genetic overlap between interleukin-8 and risk for suicide attempt. Brain Behav Immun. 2019 Aug;80:292-299. doi: 10.1016/j.bbi.2019.04.004. Epub 2019 Apr 3. PMID: 30953777
  • Knowles EEM, Mathias SR, Mollon J, Rodrigue A, Koenis MMG, Dyer TD, Goring HHH, Curran JE, Olvera RL, Duggirala R, Almasy L, Blangero J, Glahn DC. A QTL on chromosome 3q23 influences processing speed in humans.  Genes Brain Behav. 2019 Apr;18(4): e12530. doi: 10.1111/gbb.12530. Epub 2018 Nov 16 PMID: 30379395
  • Kochunov P, Donohue B, Mitchell BD, Ganjgahi H, Adhikari B, Ryan M, Medland SE, Jahanshad N, Thompson PM, Blangero J, Fieremans E, Novikov DS, Marcus D, Van Essen DC, Glahn DC, Elliot Hong L, Nichols TE.  Genomic kinship construction to enhance genetic analyses in the human connectome project data.  Hum Brain Mapp. 2019 Apr 1;40(5):1677-1688. doi: 10.1002/hbm.24479. Epub 2018 Nov 29. PMID: 30496643
  • Kotkowski E, Price LR, Franklin C, Salazar M, Woolsey M, DeFronzo RA, Blangero J, Glahn DC, Fox PT. A neural signature of metabolic syndrome. Hum Brain Mapp. 2019 Aug 15;40(12):3575-3588. doi: 10.1002/hbm.24617. Epub 2019 May 7. PMID: 31062906
  • Kowalski MH, Qian H, Hou Z, Rosen JD, Tapia AL, Shan Y, Jain D, Argos M, Arnett DK, Avery C, Barnes KC, Becker LC, Bien SA, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Buyske S, Cai J, Cho MH, Choi SH, Choquet H, Cupples LA, Cushman M, Daya M, de Vries PS, Ellinor PT, Faraday N, Fornage M, Gabriel S, Ganesh SK, Graff M, Gupta N, He J, Heckbert SR, Hidalgo B, Hodonsky CJ, Irvin MR, Johnson AD, Jorgenson E, Kaplan R, Kardia SLR, Kelly TN, Kooperberg C, Lasky-Su JA, Loos RJF, Lubitz SA, Mathias RA, McHugh CP, Montgomery C, Moon JY, Morrison AC, Palmer ND, Pankratz N, Papanicolaou GJ, Peralta JM, Peyser PA, Rich SS, Rotter JI, Silverman EK, Smith JA, Smith NL, Taylor KD, Thornton TA, Tiwari HK, Tracy RP, Wang T, Weiss ST, Weng LC, Wiggins KL, Wilson JG, Yanek LR, Zöllner S, North KE, Auer PL; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group, Raffield LM, Reiner AP, Li Y.  Use of >100,000 nhlbi trans-omics for precision medicine (topmed) consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.  PLoS Genet. 2019 Dec 23;15(12):e1008500. doi: 10.1371/journal.pgen.1008500. eCollection 2019 Dec.
  • Kumar S, Espinosa EC, Leandro AC, Curran JE, Blangero J. microRNA and mRNA interactions in induced pluripotent stem cell reprogramming of lymphoblastoid cell lines. Am J Stem Cells. 2019 Aug 15;8(2):28-37. eCollection 2019. PMID: 31523484
  • Manusov EG, Diego VP, Smith J, Garza JR 2nd, Lowdermilk J, Blangero J, Williams-Blangero S, Fernandez F. Unimóvil: A mobile health clinic providing primary care to the colonias of the Rio Grande Valley, South Texas. Front Public Health. 2019 Aug 21; 7:215. doi: 10.3389/fpubh.2019.00215. eCollection
  • Melton PE, Johnson MP, Gokhale-Agashe D, Rea AJ, Ariff A, Cadby G, Peralta JM, Mcnab TJ, Allcock RJ, Abraham LJ, Blangero J, Brennecke SP, Moses EK. Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes. J Hypertens. 2019 May;37(5):997-1011. doi: 10.1097/HJH.0000000000002023.] PMID: 30633125
  • Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE, Dedoussis GV, Lemaitre RN, Wojczynski MK, Männistö S, Ngwa JS, Kho M, Ahluwalia TS, Pervjakova N, Houston DK, Bouchard C, Huang T, Orho-Melander M, Frazier-Wood AC, Mook-Kanamori DO, Pérusse L, Pennell CE, de Vries PS, Voortman T, Li O, Kanoni S, Rose LM, Lehtimäki T, Zhao JH, Feitosa MF, Luan J, McKeown NM, Smith JA, Hansen T, Eklund N, Nalls MA, Rankinen T, Huang J, Hernandez DG, Schulz CA, Manichaikul A, Li-Gao R, Vohl MC, Wang CA, van Rooij FJA, Shin J, Kalafati IP, Day F, Ridker PM, Kähönen M, Siscovick DS, Langenberg C, Zhao W, Astrup A, Knekt P, Garcia M, Rao DC, Qi Q, Ferrucci L, Ericson U, Blangero J, Hofman A, Pausova Z, Mikkilä V, Wareham NJ, Kardia SLR, Pedersen O, Jula A, Curran JE, Zillikens MC, Viikari JS, Forouhi NG, Ordovás JM, Lieske JC, Rissanen H, Uitterlinden AG, Raitakari OT, Kiefte-de Jong JC, Dupuis J, Rotter JI, North KE, Scott RA, Province MA, Perola M, Cupples LA, Turner ST, Sørensen TIA, Salomaa V, Liu Y, Sung YJ, Qi L, Bandinelli S, Rich SS, de Mutsert R, Tremblay A, Oddy WH, Franco OH, Paus T, Florez JC, Deloukas P, Lyytikäinen LP, Chasman DI, Chu AY, Tanaka T. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2019 Dec;24(12):1920-1932. doi: 10.1038/s41380-018-0079-4. Epub 2018 Jul 9. PMID: 29988085
  • Rodrigue AL, Knowles EE, Mollon J, Mathias SR, Koenis MM, Peralta JM, Leandro AC, Fox PT, Sprooten E, Kochunov P, Olvera RL, Duggirala R, Almasy L, Curran JE, Blangero J, Glahn DC. Evidence for genetic correlation between human cerebral white matter microstructure and inflammation. Hum Brain Mapp. 2019 Oct 1;40(14):4180-4191. doi: 10.1002/hbm.24694. Epub 2019 Jun 11. PMID: 31187567
  • Sarnowski C, Leong A, Raffield LM, Wu P, de Vries PS, DiCorpo D, Guo X, Xu H, Liu Y, Zheng X, Hu Y, Brody JA, Goodarzi MO, Hidalgo BA, Highland HM, Jain D, Liu CT, Naik RP, O'Connell JR, Perry JA, Porneala BC, Selvin E, Wessel J, Psaty BM, Curran JE, Peralta JM, Blangero J, Kooperberg C, Mathias R, Johnson AD, Reiner AP, Mitchell BD, Cupples LA, Vasan RS, Correa A, Morrison AC, Boerwinkle E, Rotter JI, Rich SS, Manning AK, Dupuis J, Meigs JB; TOPMed Diabetes Working Group; TOPMed Hematology Working Group; TOPMed Hemostasis Working Group; National Heart, Lung, and Blood Institute TOPMed Consortium. Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin a1c in multi-ancestry cohorts: the trans-omics for precision medicine program. Am J Hum Genet. 2019 Oct 3;105(4):706-718. doi: 10.1016/j.ajhg.2019.08.010. Epub 2019 Sep 26. PMID:31564435
  • Adhikari BM, Jahanshad N, Shukla D, Glahn DC, Blangero J, Fox PT, Reynolds RC, Cox RW, Fieremans E, Veraart J, Novikov DS, Nichols TE, Hong LE, Thompson PM, Kochunov P.  Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline.  Hum Brain Mapp. 2018 Dec;39(12):4893-4902. doi: 10.1002/hbm.24331. Epub 2018 Jul 27.  PMID:30052318
  • Almeida M, Peralta J, Garcia J, Diego V, Goring H, Williams-Blangero S, Blangero J. Modeling methylation data as an additional genetic variance component. BMC Proc. 2018 Sep 17;12(Suppl 9):29. doi: 10.1186/s12919-018-0128-7. eCollection 2018. PMID: 30263043
  • Arya R, Escalante A, Farook VS, Restrepo JF, Battafarano DF, Almeida M, Kos MZ, Fourcaudot MJ, Mummidi S, Kumar S, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Del Rincon I. A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis. Atherosclerosis.. 2018 Apr; 271:92-101. doi: 10.1016/j.atherosclerosis.2017.11.024. Epub 2017 Nov 26. PMID: 29482039
  • Arya R, Escalante A, Farook VS, Restrepo JF, Battafarano DF, Almeida M, Kos MZ, Fourcaudot MJ, Mummidi S, Kumar S, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Del Rincon I. Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects. Data Brief. 2018 Feb 8; 17:820-829. doi: 10.1016/j.dib.2018.02.006. eCollection 2018 Apr. PMID: 29527544
  • Arya R, Farook VS, Fowler SP, Puppala S, Chittoor G, Resendez RG, Mummidi S, Vanamala J, Almasy L, Curran JE, Comuzzie AG, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Diego VP. Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents. Genet Epidemiol. 2018 Feb 20. doi: 10.1002/gepi.22114. PMID: 29460292
  • Blackburn NB, Porto A, Peralta JM, Blangero J. Heritability and genetic associations of triglyceride and HDL-C levels using pedigree-based and empirical kinships. BMC Proc. 2018 Sep 17;12(Suppl 9):34. doi: 10.1186/s12919-018-0133-x. eCollection 2018. PMID: 30263045
  • Blondell L, Blackburn A, Kos MZ, Blangero J, Göring HHH. Contribution of inbred singletons to variance component estimation of heritability and linkage. Hum Hered. 2018;83(2):92-99. doi: 10.1159/000492830. Epub 2018 Nov 2. PMID: 30391948
  • Cadby G, Melton PE, McCarthy NS, Almeida M, Williams-Blangero S, Curran JE, VandeBerg JL, Hui J, Beilby J, Musk AW, James AL, Hung J, Blangero J, Moses EK. Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study. Hum Genet. 2018 Jan;137(1):45-53. doi: 10.1007/s00439-017-1856-x. Epub 2017 Nov 27. PMID: 29181734
  • Chen JA, Fears SC, Jasinska AJ, Huang A, Al-Sharif NB, Scheibel KE, Dyer TD, Fagan AM, Blangero J, Woods R, Jorgensen MJ, Kaplan JR, Freimer NB, Coppola G. Neurodegenerative disease biomarkers Aβ1-40, Aβ1-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy. Brain Behav. 2018 Jan 13;8(2): e00903. doi: 10.1002/brb3.903. eCollection 2018 Feb. PMID: 29484263
  • Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Donohue B, Kochunov P, Nichols TE. Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. Nat Commun. 2018 Aug 14;9(1):3254. doi: 10.1038/s41467-018-05444-6. PMID: 30108209
  • Gao C, Tabb KL, Dimitrov LM, Taylor KD, Wang N, Guo X, Long J, Rotter JI, Watanabe RM, Curran JE, Blangero J, Langefeld CD, Bowden DW, Palmer ND. Exome sequencing identifies genetic variants associated with circulating lipid levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS). Sci Rep. 2018 Apr 4;8(1):5603. doi: 10.1038/s41598-018-23727-2. PMID: 29618726
  • Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zöllner S, Curran JE, Peralta J, Akolkar B, Bell GI, Burtt NP, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):379-384. doi: 10.1073/pnas.1705859115. Epub 2017 Dec 26. PMID: 29279374
  • Khan FF, Melton PE, McCarthy NS, Morar B, Blangero J, Moses EK, Jablensky A. Whole genome sequencing of 91 multiplex schizophrenia families reveals increased burden of rare, exonic copy number variation in schizophrenia probands and genetic heterogeneity. Schizophr Res. 2018 Feb 24. pii: S0920-9964(18)30095-1. doi: 10.1016/j.schres.2018.02.034. PMID: 29486958
  • Knowles EEM, Curran JE, Meikle PJ, Huynh K, Mathias SR, Göring HHH, VandeBerg JL, Mahaney MC, Jalbrzikowski M, Mosior MK, Michael LF, Olvera RL, Duggirala R, Almasy L, Glahn DC, Blangero J. Disentangling the genetic overlap between cholesterol and suicide risk. Neuropsychopharmacology. 2018 Dec;43(13):2556-2563. doi: 10.1038/s41386-018-0162-1. Epub 2018 Jul 23. PMID: 30082891
  • Kumar S, Blangero J, Curran JE. Induced pluripotent stem cells in disease modeling and gene identification. Methods Mol Biol. 2018; 1706:17-38. doi: 10.1007/978-1-4939-7471-9_2. PMID: 29423791
  • Mathias SR, Knowles EEM, Barrett J, Beetham T, Leach O, Buccheri S, Aberizk K, Blangero J, Poldrack RA, Glahn DC. Deficits in visual working-memory capacity and general cognition in African Americans with psychosis. Schizophr Res. 2018 Mar;193:100-106. doi: 10.1016/j.schres.2017.08.015. Epub 2017 Aug 23.  PMID:28843437
  • McCarthy NS, Badcock JC, Clark ML, Knowles EEM, Cadby G, Melton PE, Morgan VA, Blangero J, Moses EK, Glahn DC, Jablensky A. Assessment of cognition and personality as potential endophenotypes in the Western Australian Family Study of Schizophrenia.  Schizophr Bull. 2018 Jun 6;44(4):908-921. doi: 10.1093/schbul/sbx141.  PMID:29040798
  • McCloskey K, De Livera AM, Collier F, Ponsonby AL, Carlin JB, Vuillermin P, Mellett NA, Jayawardana K, Weir JM, Blangero J, Curran JE, Burgner D, Meikle PJ; BIS investigator group. gestational age and the cord blood lipidomic profile in late preterm and term infants. Neonatology. 2018;114(3):215-222. doi: 10.1159/000487506. Epub 2018 Jun 25. PMID: 29940570
  • Peralta JM, Blackburn NB, Porto A, Blangero J, Charlesworth J. Genome-wide linkage scan for loci influencing plasma triglyceride levels. BMC Proc. 2018 Sep 17;12(Suppl 9):52. doi: 10.1186/s12919-018-0137-6. eCollection 2018. PMID: 30275898
  • Porto A, Peralta JM, Blackburn NB, Blangero J. Reliability of genomic predictions of complex human phenotypes. BMC Proc. 2018 Sep 17;12(Suppl 9):51. doi: 10.1186/s12919-018-0138-5. eCollection 2018. PMID: 30275897
  • Ramstetter MD, Shenoy SA, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Inferring identical-by-descent sharing of sample ancestors promotes high-resolution relative detection. Am J Hum Genet. 2018 Jul 5;103(1):30-44. doi: 10.1016/j.ajhg.2018.05.008. Epub 2018 Jun 21. PMID: 29937093
  • Schmitt CA, Service SK, Jasinska AJ, Dyer TD, Jorgensen MJ, Cantor RM, Weinstock GM, Blangero J, Kaplan JR, Freimer NB.  Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus).  Int J Obes (Lond). 2018 Apr;42(4):765-774. doi: 10.1038/ijo.2017.301. Epub 2017 Dec 6.  PMID:29211707
  • Blackburn NB, Marthick JR, Banks A, Charlesworth JC, Marsden KA, Lowenthal RM, Blangero J, Dickinson JL. Evaluating a CLL susceptibility variant in ITGB2 in families with multiple sub-types of hematological malignancies. Blood. Jul 6;130(1):86-88.. doi: 10.1182/blood-2017-03-774232. Epub 2017 May 10. PMID:28490571
  • Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH Jr, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet. 2017 Jan;49(1):125-130. doi: 10.1038/ng.3738. Epub 2016 Dec 5. PMID:27918534 
  • Farook VS, Reddivari L, Mummidi S, Puppala S, Arya R, Lopez-Alvarenga JC, Fowler SP, Chittoor G, Resendez RG, Kumar BM, Comuzzie AG, Curran JE, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Vanamala JK. Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children. Am J Clin Nutr. 2017 Jul; 106(1):52-58. doi: 10.3945/ajcn.116.144006. Epub 2017 May 17. PMID:28515064
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  • Hodgson K, Poldrack RA, Curran JE, Knowles EE, Mathias S, Göring HHH, Yao N, Olvera RL, Fox PT, Almasy L, Duggirala R, Barch DM, Blangero J, Glahn DC. Shared genetic factors influence head motion during MRI and Body Mass Index. Cereb Cortex. 2017 Dec 1;27(12):5539-5546. doi: 10.1093/cercor/bhw321. PMID 27744290
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  • Knowles EE, Huynh K, Meikle PJ, Göring HH, Olvera RL, Mathias SR, Duggirala R, Almasy L, Blangero J, Curran JE, Glahn DC. The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk. Eur Psychiatry. 2017 Feb 21; 43:44-50. doi: 10.1016/j.eurpsy.2017.02.479. [Epub ahead of print] PMID:28365467
  • Knowles EE, Meikle PJ, Huynh K, Göring HH, Olvera RL, Mathias SR, Duggirala R, Almasy L, Blangero J, Curran JE, Glahn DC. Serum phosphatidylinositol as a biomarker for bipolar disorder liability. Bipolar Disord. 2017 Mar;19(2):107-115. doi: 10.1111/bdi.12468. Epub 2017 Feb 23. PMID:28230325
  • Kulkarni H, Mamtani M, Wong G, Weir JM, Barlow CK, Dyer TD, Almasy L, Mahaney MC, Comuzzie AG, Duggirala R, Meikle PJ, Blangero J, Curran JE. Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families. BMC Genet.2017 May 19;18(1):48. doi: 10.1186/s12863-017-0515-5. PMID:28525987 
  • Kulkarni H, Mamtani M, Blangero J, Curran JE. Lipidomics in the study of hypertension in metabolic syndrome. Curr Hypertens Rep. 2017 Jan;19(1):7. doi: 10.1007/s11906-017-0705-6. Review. PMID:28168678
  • Lake NJ, Taylor RL, Trahair H, Harikrishnan KN, Curran JE, Almeida M, Kulkarni H, Mukhamedova N, Hoang A, Low H, Murphy AJ, Johnson MP, Dyer TD, Mahaney MC, Göring HHH, Moses EK, Sviridov D, Blangero J, Jowett JBM, Bozaoglu K. TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis. Eur Heart J. 2017 Dec 21;38(48):3579-3587. doi: 10.1093/eurheartj/ehx315. PMID: 28655204
  • Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JR, Rayner NW, Robertson NR, Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SB, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T, Lindstrom J, Brandslund I, Christensen C, Surdulescu GL, Lakka TA, Doney AS, Nilsson P, Wareham NJ, Langenberg C, Varga TV, Franks PW, Rolandsson O, Rosengren AH, Farook VS, Thameem F, Puppala S, Kumar S, Lehman DM, Jenkinson CP, Curran JE, Hale DE, Fowler SP, Arya R, DeFronzo RA, Abboud HE, Syvänen AC, Hicks PJ, Palmer ND, Ng MC, Bowden DW, Freedman BI, Esko T, Mägi R, Milani L, Mihailov E, Metspalu A, Narisu N, Kinnunen L, Bonnycastle LL, Swift A, Pasko D, Wood AR, Fadista J, Pollin TI, Barzilai N, Atzmon G, Glaser B, Thorand B, Strauch K, Peters A, Roden M, Müller-Nurasyid M, Liang L, Kriebel J, Illig T, Grallert H, Gieger C, Meisinger C, Lannfelt L, Musani SK, Griswold M, Taylor HA Jr, Wilson G Sr, Correa A, Oksa H, Scott WR, Afzal U, Tan ST, Loh M, Chambers JC, Sehmi J, Kooner JS, Lehne B, Cho YS, Lee JY, Han BG, Käräjämäki A, Qi Q, Qi L, Huang J, Hu FB, Melander O, Orho-Melander M, Below JE, Aguilar D, Wong TY, Liu J, Khor CC, Chia KS, Lim WY, Cheng CY, Chan E, Tai ES, Aung T, Linneberg A, Isomaa B, Meitinger T, Tuomi T, Hakaste L, Kravic J, Jørgensen ME, Lauritzen T, Deloukas P, Stirrups KE, Owen KR, Farmer AJ, Frayling TM, O'Rahilly SP, Walker M, Levy JC, Hodgkiss D, Hattersley AT, Kuulasmaa T, Stančáková A, Barroso I, Bharadwaj D, Chan J, Chandak GR, Daly MJ, Donnelly PJ, Ebrahim SB, Elliott P, Fingerlin T, Froguel P, Hu C, Jia W, Ma RC, McVean G, Park T, Prabhakaran D, Sandhu M, Scott J, Sladek R, Tandon N, Teo YY, Zeggini E, Watanabe RM, Koistinen HA, Kesaniemi YA, Uusitupa M, Spector TD, Salomaa V, Rauramaa R, Palmer CN, Prokopenko I, Morris AD, Bergman RN, Collins FS, Lind L, Ingelsson E, Tuomilehto J, Karpe F, Groop L, Jørgensen T, Hansen T, Pedersen O, Kuusisto J, Abecasis G, Bell GI, Blangero J, Cox NJ, Duggirala R, Seielstad M, Wilson JG, Dupuis J, Ripatti S, Hanis CL, Florez JC, Mohlke KL, Meigs JB, Laakso M, Morris AP, Boehnke M, Altshuler D, McCarthy MI, Gloyn AL, Lindgren CM. A low-frequency inactivating Akt2variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk. Diabetes. 2017 Jul;66(7):2019-2032. doi: 10.2337/db16-1329. Epub 2017 Mar 24. PMID:28341696 
  • Mathias SR, Knowles EEM, Barrett J, Leach O, Buccheri S, Beetham T, Blangero J, Poldrack RA, Glahn DC. The processing-speed impairment in psychosis is more than just accelerated aging. Schizophr Bull. 2017 Jul 1;43(4):814-823. doi: 10.1093/schbul/sbw168. PMID: 28062652
  • McCarthy NS, Melton PE, Ward SV, Allan SM, Dragovic M, Clark ML, Morar B, Rubio JP, Blangero J, Badcock JC, Morgan VA, Moses EK, Jablensky A. Exome array analysis suggests an increased variant burden in families with schizophrenia. Schizophr Res. 2017 Jul; 185:9-16. doi: 10.1016/j.schres.2016.12.007. Epub 2016 Dec 9. PMID: 27939555
  • Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macías H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordoñez-Sánchez ML, Rodríguez-Guillen R, Rodríguez-Torres M, Segura-Kato Y, García-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonàs-Guarch S, Hartl C, Ripke S; Diabetes Prevention Program Research Group, Tooley K, Lane J, Zerrweck C, Martínez-Hernández A, Córdova EJ, Mendoza-Caamal E, Contreras-Cubas C, González-Villalpando ME, Cruz-Bautista I, Muñoz-Hernández L, Gómez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M; Broad Genomics Platform, Gabriel S; T2D-GENES Consortium, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, González-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusié-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC. A loss-of-function splice acceptor variant in IGF2 is protective for Type 2 Diabetes. SIGMA T2D Genetics Consortium. Diabetes. 2017 Nov;66(11):2903-2914. doi: 10.2337/db17-0187. Epub 2017 Aug 24. PMID: 28838971
  • Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Benchmarking relatedness inference methods with genome-wide data from thousands of relatives. Genetics. 2017 Sep;207(1):75-82. doi: 10.1534/genetics.117.1122. Epub 2017 Jul 24.  PMID: 28739658. 
  • Sanders SJ, Neale BM, Huang H, Werling DM, An JY, Dong S, Abecasis G, Arguello PA, Blangero J, Boehnke M, Daly MJ, Eggan K, Geschwind DH, Glahn DC, Goldstein DB, Gur RE, Handsaker RE, McCarroll SA, Ophoff RA, Palotie A, Pato CN, Sabatti C, State MW, Willsey AJ, Hyman SE, Addington AM, Lehner T, Freimer NB. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2017 Dec;20(12):1661-1668. doi: 10.1038/s41593-017-0017-9. PMID: 29184211
  • Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW. Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Ann Hum Genet. 2017 Mar;81(2):49-58. doi: 10.1111/ahg.12184. Epub 2017 Jan 9. PMID:28067407 
  • Weerasekera L, Rudnicka C, Sang QX, Curran JE, Johnson MP, Moses EK, Göring HH, Blangero J, Hricova J, Schlaich M, Matthews VB. ADAM19: A novel target for Metabolic Syndrome in humans and mice. Mediators Inflamm. 2017; 2017:7281986. doi: 10.1155/2017/7281986. Epub 2017 Feb 7. PMID:28265178 
  • Yao L, Liu Y, Qiu Z, Kumar S, Curran JE, Blangero J, Chen Y, Lehman DM. Molecular profiling of human induced pluripotent stem cell-derived hypothalamic neurones provides developmental insights into genetic loci for body weight regulation. J Neuroendocrinol. 2017 Feb;29(2). doi: 10.1111/jne.12455. PMID:28071834
  • Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. Fast genome-wide QTL association mapping on pedigree and population data. Genet Epidemiol. 2017 Apr;41(3):174-186. doi: 10.1002/gepi.21988. Epub 2016 Dec 12. PMID:27943406

Collaborating Institutions

  • Menzies Institute for Medical Research

  • University of Pennsylvania

  • Yale University

  • National Institute for Mental Health

  • University of Pittsburgh

  • University of Costa Rica

  • University of Tasmania, Australia

  • University of Edinburgh

  • University of Western Australia