The South Texas Diabetes and Obesity Institute (STDOI) was established on October 13, 2014, to be a focus for world-class biomedical research programs at the new UTRGV School of Medicine. With diverse research efforts in the areas of diabetes, obesity, heart disease, ocular health, psychiatric disease, osteoporosis, and infectious diseases of border health relevance such as Chagas disease and tuberculosis, the STDOI is working to address the most critical public health problems in the Rio Grande Valley region. The Institute has state of the art laboratories and genetic research capabilities, an 11,000 processor computer cluster dedicated to genetic analysis, a biorepository containing tens of thousands of samples collected in the STDOI’s numerous studies of complex disease, and a colony of the unique animal model Monodelphis domestica.