Thomas Dyer Ph.D.

Faculty Profile Picture

Professor of Research

South Texas Diabetes and Obesity Institute

School of Medicine

Office: San Antonio Technology Center, Room 320.08
3463 Magic Drive
San Antonio, TX.  78229
Phone: +1 (210)-585-9769
Email: thomas.dyer@utrgv.edu

Education

2002 Ph.D. Computer Science, University of Texas at San Antonio

1986 M.S. Computer Science, University of Texas at San Antonio

Research Focus

The focus of Dr. Dyer’s research is on computational methods for disease-related gene detection and gene identification. STDOI investigators developed SOLAR, a genetic analysis package that has over 5000 users. Dr. Dyer’s work focuses in part on refinement and further development of algorithms that will enhance the utility of SOLAR for genetic research. Another area of long-term research interest is the use of computer simulation approaches for testing statistical genetic methods.

Extramural Appointments

    
  • Member, T2D-GENES (Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples)  Consortium

  • Member, ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium

  • Member, CHARGE (Cohorts for Heart and Aging Research in Genetic Epidemiology) Consortium

Recent Publications

Journal Articles

  • Hodgson K, Almasy L, Knowles EE, Kent JW, Curran JE, Dyer TD, Göring HH, Olvera RL, Fox PT, Pearlson GD, Krystal JH, Duggirala R, Blangero J, Glahn DC. Genome-wide significant loci for addiction and anxiety. Eur Psychiatry. 2016 Jun 15;36:47-54. doi: 10.1016/j.eurpsy.2016.03.004. [Epub ahead of print] PubMed PMID: 27318301.

  • Mamtani M, Kulkarni H, Wong G, Weir JM, Barlow CK, Dyer TD, Almasy L, Mahaney MC, Comuzzie AG, Glahn DC, Magliano DJ, Zimmet P, Shaw J, Williams-Blangero S, Duggirala R, Blangero J, Meikle PJ, Curran JE. Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: Results from diverse cohorts. Lipids Health Dis. 2016 Apr 4;15(1):67. doi: 10.1186/s12944-016-0234-3. PubMed PMID: 27044508; PubMed Central PMCID: PMC4820916.

  • Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept. Nat Neurosci. 2016 Mar;19(3):420-31. doi: 10.1038/nn.4228. Epub 2016 Feb 1. PubMed PMID: 26854805; PubMed Central PMCID: PMC4852730.

  • Knowles EE, Kent JW Jr, McKay DR, Sprooten E, Mathias SR, Curran JE, Carless MA, Almeida MA, Göring HH, Dyer TD, Olvera RL, Fox PT, Duggirala R, Almasy L, Blangero J, Glahn DC. Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression. J Affect Disord. 2016 Feb;191:123-31. doi: 10.1016/j.jad.2015.11.012. Epub 2015 Nov 17. PubMed PMID: 26655122; PubMed Central PMCID: PMC4715913.

  • Clark MM, Blangero J, Dyer TD, Sobel EM, Sinsheimer JS. The Quantitative-MFG Test: A linear mixed effect model to detect maternal-offspring gene interactions. Ann Hum Genet. 2016 Jan;80(1):63-80. doi: 10.1111/ahg.12137. Epub 2015 Nov 15. PubMed PMID: 26567478; PubMed Central PMCID: PMC4715557.

  • Mamtani M, Kulkarni H, Dyer TD, Göring HH, Neary JL, Cole SA, Kent JW, Kumar S, Glahn DC, Mahaney MC, Comuzzie AG, Almasy L, Curran JE, Duggirala R, Blangero J, Carless MA. Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families. Clin Epigenetics. 2016 Jan 20;8:6. doi: 10.1186/s13148-016-0173-x. eCollection 2016. PubMed PMID: 26798409; PubMed Central PMCID: PMC4721061.

  • Mathias SR, Knowles EE, Kent JW Jr, McKay DR, Curran JE, Almeida MA, Dyer TD, Göring HH, Olvera RL, Duggirala R, Fox PT, Almasy L, Blangero J, Glahn DC. Recurrent major depression and right hippocampal volume: A bivariate linkage and association study. Hum Brain Mapp. 2016 Jan;37(1):191-202. doi: 10.1002/hbm.23025. Epub 2015 Oct 20. PubMed PMID: 26485182.

  • Kulkarni H, Mamtani M, Peralta J, Almeida M, Dyer TD, Göring HH, Johnson MP, Duggirala R, Mahaney MC, Olvera RL, Almasy L, Glahn DC, Williams-Blangero S, Curran JE, Blangero J. Soluble forms of intercellular and vascular cell adhesion molecules independently predict progression to type 2 diabetes in Mexican American families. PLoS One. 2016 Mar 23;11(3):e0151177. doi: 10.1371/journal.pone.0151177. eCollection 2016. PubMed PMID: 27007680; PubMed Central PMCID: PMC4805238.

  • Sprooten E, Gupta CN, Knowles EE, McKay DR, Mathias SR, Curran JE, Kent JW Jr, Carless MA, Almeida MA, Dyer TD, Göring HH, Olvera RL, Kochunov P, Fox PT, Duggirala R, Almasy L, Calhoun VD, Blangero J, Turner JA, Glahn DC. Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):678-86. doi: 10.1002/ajmg.b.32360. Epub 2015 Oct 5. PubMed PMID: 26440917; PubMed Central PMCID: PMC4639444.

  • Kim YJ, Lee J, Kim BJ; T2D-Genes Consortium, Park T. A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data. BMC Genomics. 2015 Dec 29;16:1109. doi: 10.1186/s12864-015-2192-y. PubMed PMID: 26715385; PubMed Central PMCID: PMC4696174.

  • Rubicz R, Yolken R, Drigalenko E, Carless MA, Dyer TD, Kent J Jr, Curran JE, Johnson MP, Cole SA, Fowler SP, Arya R, Puppala S, Almasy L, Moses EK, Kraig E, Duggirala R, Blangero J, Leach CT, Göring HH. Genome-wide genetic investigation of serological measures of common infections. Eur J Hum Genet. 2015 Nov;23(11):1544-8. doi: 10.1038/ejhg.2015.24. Epub 2015 Mar 11. PubMed PMID: 25758998; PubMed Central PMCID: PMC4613484.

  • Kulkarni H, Kos MZ, Neary J, Dyer TD, Kent JW Jr, Göring HH, Cole SA, Comuzzie AG, Almasy L, Mahaney MC, Curran JE, Blangero J, Carless MA. Novel epigenetic determinants of type 2 diabetes in Mexican-American families. Hum Mol Genet. 2015 Sep 15;24(18):5330-44. doi: 10.1093/hmg/ddv232. Epub 2015 Jun 22. PubMed PMID: 26101197; PubMed Central PMCID: PMC4550817.

  • Blackburn A, Almeida M, Dean A, Curran JE, Johnson MP, Moses EK, Abraham LJ, Carless MA, Dyer TD, Kumar S, Almasy L, Mahaney MC, Comuzzie A, Williams-Blangero S, Blangero J, Lehman DM, Göring HH. Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans. Eur J Hum Genet. 2015 Sep;23(9):1229-35. doi: 10.1038/ejhg.2014.280. Epub 2015 Jan 14. PubMed PMID: 25585699; PubMed Central PMCID: PMC4538210.

  • Huang YS, Ramensky V, Service SK, Jasinska AJ, Jung Y, Choi OW, Cantor RM, Juretic N, Wasserscheid J, Kaplan JR, Jorgensen MJ, Dyer TD, Dewar K, Blangero J, Wilson RK, Warren W, Weinstock GM, Freimer NB. Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits. BMC Biol. 2015 Jun 20;13:41. doi: 10.1186/s12915-015-0152-2. PubMed PMID: 26092298; PubMed Central PMCID: PMC4494155.

  • Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, Bralten J, Brown AA, Chakravarty MM, Chen Q, Ching CR, Cuellar-Partida G, den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T, Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S, Klein M, Kraemer B, Lee PH, Olde Loohuis LM, Luciano M, Macare C, Mather KA, Mattheisen M, Milaneschi Y, Nho K, Papmeyer M, Ramasamy A, Risacher SL, Roiz-Santiañez R, Rose EJ, Salami A, Sämann PG, Schmaal L, Schork AJ, Shin J, Strike LT, Teumer A, van Donkelaar MM, van Eijk KR, Walters RK, Westlye LT, Whelan CD, Winkler AM, Zwiers MP, Alhusaini S, Athanasiu L, Ehrlich S, Hakobjan MM, Hartberg CB, Haukvik UK, Heister AJ, Hoehn D, Kasperaviciute D, Liewald DC, Lopez LM, Makkinje RR, Matarin M, Naber MA, McKay DR, Needham M, Nugent AC, Pütz B, Royle NA, Shen L, Sprooten E, Trabzuni D, van der Marel SS, van Hulzen KJ, Walton E, Wolf C, Almasy L, Ames D, Arepalli S, Assareh AA, Bastin ME, Brodaty H, Bulayeva KB, Carless MA, Cichon S, Corvin A, Curran JE, Czisch M, de Zubicaray GI, Dillman A, Duggirala R, Dyer TD, Erk S, Fedko IO, Ferrucci L, Foroud TM, Fox PT, Fukunaga M, Gibbs JR, Göring HH, Green RC, Guelfi S, Hansell NK, Hartman CA, Hegenscheid K, Heinz A, Hernandez DG, Heslenfeld DJ, Hoekstra PJ, Holsboer F, Homuth G, Hottenga JJ, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Kanai R, Keil M, Kent JW Jr, Kochunov P, Kwok JB, Lawrie SM, Liu X, Longo DL, McMahon KL, Meisenzahl E, Melle I, Mohnke S, Montgomery GW, Mostert JC, Mühleisen TW, Nalls MA, Nichols TE, Nilsson LG, Nöthen MM, Ohi K, Olvera RL, Perez-Iglesias R, Pike GB, Potkin SG, Reinvang I, Reppermund S, Rietschel M, Romanczuk-Seiferth N, Rosen GD, Rujescu D, Schnell K, Schofield PR, Smith C, Steen VM, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Turner JA, Valdés Hernández MC, van 't Ent D, van der Brug M, van der Wee NJ, van Tol MJ, Veltman DJ, Wassink TH, Westman E, Zielke RH, Zonderman AB, Ashbrook DG, Hager R, Lu L, McMahon FJ, Morris DW, Williams RW, Brunner HG, Buckner RL, Buitelaar JK, Cahn W, Calhoun VD, Cavalleri GL, Crespo-Facorro B, Dale AM, Davies GE, Delanty N, Depondt C, Djurovic S, Drevets WC, Espeseth T, Gollub RL, Ho BC, Hoffmann W, Hosten N, Kahn RS, Le Hellard S, Meyer-Lindenberg A, Müller-Myhsok B, Nauck M, Nyberg L, Pandolfo M, Penninx BW, Roffman JL, Sisodiya SM, Smoller JW, van Bokhoven H, van Haren NE, Völzke H, Walter H, Weiner MW, Wen W, White T, Agartz I, Andreassen OA, Blangero J, Boomsma DI, Brouwer RM, Cannon DM, Cookson MR, de Geus EJ, Deary IJ, Donohoe G, Fernández G, Fisher SE, Francks C, Glahn DC, Grabe HJ, Gruber O, Hardy J, Hashimoto R, Hulshoff Pol HE, Jönsson EG, Kloszewska I, Lovestone S, Mattay VS, Mecocci P, McDonald C, McIntosh AM, Ophoff RA, Paus T, Pausova Z, Ryten M, Sachdev PS, Saykin AJ, Simmons A, Singleton A, Soininen H, Wardlaw JM, Weale ME, Weinberger DR, Adams HH, Launer LJ, Seiler S, Schmidt R, Chauhan G, Satizabal CL, Becker JT, Yanek L, van der Lee SJ, Ebling M, Fischl B, Longstreth WT Jr, Greve D, Schmidt H, Nyquist P, Vinke LN, van Duijn CM, Xue L, Mazoyer B, Bis JC, Gudnason V, Seshadri S, Ikram MA; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN; IMAGEN; SYS, Martin NG, Wright MJ, Schumann G, Franke B, Thompson PM, Medland SE. Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 9;520(7546):224-9. doi: 0.1038/nature14101. Epub 2015 Jan 21. PubMed PMID: 25607358; PubMed Central PMCID: PMC4393366.

  • Williams AL, Genovese G, Dyer T, Altemose N, Truax K, Jun G, Patterson N, Myers SR, Curran JE, Duggirala R, Blangero J, Reich D, Przeworski M; T2D-GENES Consortium. Non-crossover gene conversions show strong GC bias and unexpected clustering in humans. Elife. 2015 Mar 25;4. doi: 10.7554/eLife.04637. PubMed PMID: 25806687; PubMed Central PMCID: PMC4404656.

  • Knowles EE, McKay DR, Kent JW Jr, Sprooten E, Carless MA, Curran JE, Almeida MA, Dyer TD, Göring HH, Olvera RL, Duggirala R, Fox PT, Almasy L, Blangero J, Glahn DC. Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. Am J Psychiatry. 2015 Feb 1;172(2):190-9. doi: 10.1176/appi.ajp.2014.14030311. Epub 2014 Oct 31. PubMed PMID: 25322361; PubMed Central PMCID: PMC4314438.

  • Glahn DC, Williams JT, McKay DR, Knowles EE, Sprooten E, Mathias SR, Curran JE, Kent JW Jr, Carless MA, Göring HH, Dyer TD, Woolsey MD, Winkler AM, Olvera RL, Kochunov P, Fox PT, Duggirala R, Almasy L, Blangero J. Discovering schizophrenia endophenotypes in randomly ascertained pedigrees. Biol Psychiatry. 2015 Jan 1;77(1):75-83. doi: 10.1016/j.biopsych.2014.06.027. Epub 2014 Jul 21. PubMed PMID: 25168609; PubMed Central PMCID: PMC4261014.

  • Dager AD, McKay DR, Kent JW Jr, Curran JE, Knowles E, Sprooten E, Göring HH, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared genetic factors influence amygdala volumes and risk for alcoholism. Neuropsychopharmacology. 2015 Jan;40(2):412-20. doi: 10.1038/npp.2014.187. Epub 2014 Jul 31. PubMed PMID: 25079289; PubMed Central PMCID: PMC4443955.

  • Curran JE, Kumar S, Cromack DT, Hu SL, Coletta DK, Dyer TD, Arya R, Carless M, Tripathy D, Blangero J, Duggirala R, Göring HH, DeFronzo RA, Jenkinson CP. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). (2015) World Biomedical Frontiers, Diabetes and Obesity Section ISSN; published online. ISSN: 2328-0166. http://biomedfrontiers.org/diabetes-obesity-2015-9-11/

  • Winnier DA, Fourcaudot M, Norton L, Abdul-Ghani MA, Hu SL, Farook VS, Coletta DK, Kumar S, Puppala S, Chittoor G, Dyer TD, Arya R, Carless M, Lehman DM, Curran JE, Cromack DT, Tripathy D, Blangero J, Duggirala R, Göring HH, DeFronzo RA, Jenkinson CP. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). PLoS One. 2015 Apr 1;10(4):e0119941. doi: 10.1371/journal.pone.0119941. eCollection 2015. PubMed PMID: 25830378; PubMed Central PMCID: PMC4382323.

Collaborating Institutions

  • University of California Los Angeles

  • University of Maryland

  • University of Tasmania

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