Srinivas Mummidi Ph.D.

Faculty Profile Picture

Associate Professor of Research

South Texas Diabetes and Obesity Institute

School of Medicine

Office: Edinburg Research Education Building, Room 2.120

1214 West Schunior Street

Edinburg, TX 78541

Phone: +1 (956)-665-6423
Email: srinivas.mummidi@utrgv.edu

Education

1996 Ph.D. Immunobiology, Iowa State University, Ames, OH

1990 M.S. Veterinary Immunology, Indian Veterinary Research Institute


Research Focus

Dr. Mummidi’s long-term research focus is on understanding the functional mechanisms of single nucleotide polymorphisms modulate gene expression in the context of disease pathogenesis. Dr. Mummidi has conducted extensive research on the regulation of genes involved in inflammation to define gene structure, identify cis-regulatory elements and regions, and determine how polymorphisms disrupt DNA-protein interactions leading to changes in gene expression with implications for disease pathogens.

Dr. Mummidi’s ongoing research examines the impact of 3’UTR polymorphisms on the stability and translatability of transcripts encoded by clinically relevant genes involved in inflammatory/immune response. These studies will use state-of-the-art technologies such as genome engineering and induced pluripotent stem cells.

Extramural Appointments

    
  • Academic Editor, PLoS ONE

  • Member, Editorial Board, World Journal of Medical Genetics

Recent Publications

Journal Articles

  • Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4762-71. doi: 10.1073/pnas.1423228112. Epub 2015 Aug 11. PubMed PMID: 26307764; PubMed Central PMCID: PMC4553789.

  • Somanna NK, Yariswamy M, Garagliano JM, Siebenlist U, Mummidi S, Valente AJ, Chandrasekar B. Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2. Cell Signal. 2015 Oct;27(10):1928-38. doi: 10.1016/j.cellsig.2015.07.001. Epub 2015 Jul 4. PubMed PMID: 26148936.


Collaborating Institutions

  • University of Missouri School of Medicine

  • University of Texas Health Science Center at San Antonio


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