Satish Kumar Ph.D.

Faculty Profile Picture

Assistant Professor of Research

South Texas Diabetes and Obesity Institute

School of Medicine

Office: Edinburg Research Education Building, Room 2.116
1214 West Schunior Street
Edinburg, TX.  78541
Phone: +1 (956)-665-6477
Email: satish.kumar@utrgv.edu

Education

2003 Ph.D. Anthropology, University of Delhi, New Delhi, India
1996 M.Sc. Anthropology (Specialization: Biological Anthropology), University of Delhi, New Delhi, India
1994 B.Sc. Botany (Honours), Zoology and Chemistry, University of Delhi, New Delhi, India

Research Focus

Dr. Kumar’s research focuses on the induced pluripotent stem cell (iPSC) based modeling of human complex disorders to identify and better understand the cellular and molecular mechanisms involved, and the underlying genetic component influencing, the disease phenotype. The breakthrough development of iPSC technology represents a quantum leap in experimental modeling of human diseases, providing investigators with a self-renewing and, thus, unlimited, source of pluripotent cells for targeted differentiation into disease specific cell/tissue types, which are often difficult to obtain, sometimes requiring invasive surgery or only becoming available post-mortem.

Dr. Kumar optimized an efficient lymphoblastoid cell line (LCL) to iPSC reprogramming method, achieving 100% reprogramming success (>80 established iPSC lines) and high reprogramming efficiency. Using this methodology and a rich supply of LCLs established using the peripheral blood mononuclear cells (PBMCs) collected from more than 1400 Mexican American participants of the San Antonio Family Heart Study (SAFHS), he has been successfully generating functionally relevant target cell types (e.g. neural stem cells, neurons, functional cardiomyocytes and hepatocytes) for a variety of ongoing studies at STDOI. He has also been using the iPSC-generated neurons to develop a “population based in-vitro stroke model to identify genes influencing neural death and neuroprotection following an ischaemic stroke event”. In another project “Novel approaches to understanding the role of genetics in Parkinson’s disease (PD)”, he has used iPSC-based methods to generate neural stem cells (NSCs) from existing PD specific blood cell lines.

Apart from his current endeavor in developing iPSC methodologies, Dr. Kumar also has a strong interest in mitochondrial DNA variation and retrograde regulation, telomere length variations, its genetic regulation and maintenance mechanisms and human phylogenetics.    

Extramural Appointments

    
  • Member, Editorial Board, AIMS Cell and Tissue Engineering

Publication Highlights

  • Yao L, Liu Y, Qiu Z, Kumar S, Curran JE, Blangero J, Chen Y, Lehman DM.(2017) Molecular profiling of human iPS-derived hypothalamic neurons provides developmental insights to genetic loci for body weight regulation. Journal of Neuroendocrinology, 2017, 29. PMID: 28071834. doi: 10.1111/jne.12455
  • Kumar S, Curran JE, Glahn DC, Blangero J. Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation. Stem Cells Int. 2016;2016:2349261. Epub 2016 Jun 7. PubMed PMID: 27375745; PubMed Central PMCID: PMC4914736. doi: 10.1155/2016/2349261
  • Kumar S, Bellis C, Zlojutro M, Melton P, Blangero J, and Curran JE (2011) Large-scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins. BMC Evol Biol., 11(1): 293. PMCID: PMC3217880. doi: 10.1186/1471-2148-11-293

Recent Publications

Book Chapters

  • Kumar S, Blangero J, Curran JE. Induced Pluripotent Stem Cells in Disease Modeling and Gene Identification. In: Disease Gene Identification: Methods and Protocols, Steffano J (ed.), New York: Humana Press. (in press).
  • Kumar S, Kingsley C and DiStefano. The human genome project: where are we now and where are we going. Pp. 7-31. In Genome Mapping and Genomics in Human and Non-Human Primates. R Duggirala, L Almasy, S Williams-Blangero, S Paul, C. Kole (eds). Springer-Verlag Berlin Heidelberg, 2015.

Journal Articles

  • Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JR, Rayner NW, Robertson NR, Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SB, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T, Lindstrom J, Brandslund I, Christensen C, Surdulescu GL, Lakka TA, Doney AS, Nilsson P, Wareham NJ, Langenberg C, Varga TV, Franks PW, Rolandsson O, Rosengren AH, Farook VS, Thameem F, Puppala S, Kumar S, Lehman DM, Jenkinson CP, Curran JE, Hale DE, Fowler SP, Arya R, DeFronzo RA, Abboud HE, Syvänen AC, Hicks PJ, Palmer ND, Ng MC, Bowden DW, Freedman BI, Esko T, Mägi R, Milani L, Mihailov E, Metspalu A, Narisu N, Kinnunen L, Bonnycastle LL, Swift A, Pasko D, Wood AR, Fadista J, Pollin TI, Barzilai N, Atzmon G, Glaser B, Thorand B, Strauch K, Peters A, Roden M, Müller-Nurasyid M, Liang L, Kriebel J, Illig T, Grallert H, Gieger C, Meisinger C, Lannfelt L, Musani SK, Griswold M, Taylor HA Jr, Wilson G Sr, Correa A, Oksa H, Scott WR, Afzal U, Tan ST, Loh M, Chambers JC, Sehmi J, Kooner JS, Lehne B, Cho YS, Lee JY, Han BG, Käräjämäki A, Qi Q, Qi L, Huang J, Hu FB, Melander O, Orho-Melander M, Below JE, Aguilar D, Wong TY, Liu J, Khor CC, Chia KS, Lim WY, Cheng CY, Chan E, Tai ES, Aung T, Linneberg A, Isomaa B, Meitinger T, Tuomi T, Hakaste L, Kravic J, Jørgensen ME, Lauritzen T, Deloukas P, Stirrups KE, Owen KR, Farmer AJ, Frayling TM, O'Rahilly SP, Walker M, Levy JC, Hodgkiss D, Hattersley AT, Kuulasmaa T, Stančáková A, Barroso I, Bharadwaj D, Chan J, Chandak GR, Daly MJ, Donnelly PJ, Ebrahim SB, Elliott P, Fingerlin T, Froguel P, Hu C, Jia W, Ma RC, McVean G, Park T, Prabhakaran D, Sandhu M, Scott J, Sladek R, Tandon N, Teo YY, Zeggini E, Watanabe RM, Koistinen HA, Kesaniemi YA, Uusitupa M, Spector TD, Salomaa V, Rauramaa R, Palmer CN, Prokopenko I, Morris AD, Bergman RN, Collins FS, Lind L, Ingelsson E, Tuomilehto J, Karpe F, Groop L, Jørgensen T, Hansen T, Pedersen O, Kuusisto J, Abecasis G, Bell GI, Blangero J, Cox NJ, Duggirala R, Seielstad M, Wilson JG, Dupuis J, Ripatti S, Hanis CL, Florez JC, Mohlke KL, Meigs JB, Laakso M, Morris AP, Boehnke M, Altshuler D, McCarthy MI, Gloyn AL, Lindgren CM. (2017) A low-frequency inactivating AKT2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk. Diabetes. 2017 Mar 24. 10.2337/db16-1329. [Epub ahead of print] PubMed PMID: 28341696.

  • Yao L, Liu Y, Qiu Z, Kumar S, Curran JE, Blangero J, Chen Y, Lehman DM.(2017) Molecular profiling of human iPS-derived hypothalamic neurons provides developmental insights to genetic loci for body weight regulation. Journal of Neuroendocrinology, 2017, 29, 10.1111/jne.12455. PMID: 28071834

  • Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, Fuchsberger C, Kent JW Jr, Aguilar DA, Below JE, Farook VS, Arya R, Fowler S, Blackwell TW, Puppala S, Kumar S, Glahn DC, Moses EK, Curran JE, Thameem F, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis C, Abecasis G, Boehnke M, Göring H, Duggirala R, Almasy L. (2016) Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proceedings, 10(Suppl 7):71-77. PMID: 27980614 PMCID: PMC5133484

  • Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabé de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI. (2016) The genetic architecture of type 2 diabetes. Nature, 536(7614):41-7. PMID: 27398621 PMCID: PMC5034897

  • Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R. Prosaposin is a regulator of progranulin levels and oligomerization. Nat Commun. 2016 Jun 30;7:11992. doi: 10.1038/ncomms11992. PubMed PMID: 27356620.

  • Kumar S, Curran JE, Glahn DC, Blangero J. Utility of lymphoblastoid cell lines for induced pluripotent stem cell generation. Stem Cells Int. 2016;2016:2349261. doi: 10.1155/2016/2349261. Epub 2016 Jun 7. PubMed PMID: 27375745; PubMed Central PMCID: PMC4914736.

  • Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C. Analysis of SLC16A11 variants in 12,811 American Indians: Genotype-obesity interaction for Type 2 diabetes and an association with RNASEK expression. Diabetes. 2016 Feb;65(2):510-9. doi: 10.2337/db15-0571. Epub 2015 Oct 20. PubMed PMID: 26487785; PubMed Central PMCID: PMC4747458.

  • Mamtani M, Kulkarni H, Dyer TD, Göring HH, Neary JL, Cole SA, Kent JW, Kumar S, Glahn DC, Mahaney MC, Comuzzie AG, Almasy L, Curran JE, Duggirala R, Blangero J, Carless MA. Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families. Clin Epigenetics. 2016 Jan 20;8:6. doi: 10.1186/s13148-016-0173-x. eCollection 2016. PubMed PMID: 26798409; PubMed Central PMCID: PMC4721061.

  • Arya R, Del Rincon I, Farook VS, Restrepo JF, Winnier DA, Fourcaudot MJ, Battafarano DF, Almeida M, Kumar S, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Escalante A. Genetic variants influencing joint damage in Mexican Americans and European Americans with rheumatoid arthritis. Genet Epidemiol. 2015 Dec;39(8):678-88. doi: 10.1002/gepi.21938. Epub 2015 Oct 26. PubMed PMID: 26498133.

  • Blackburn A, Almeida M, Dean A, Curran JE, Johnson MP, Moses EK, Abraham LJ, Carless MA, Dyer TD, Kumar S, Almasy L, Mahaney MC, Comuzzie A, Williams-Blangero S, Blangero J, Lehman DM, Göring HH. Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans. Eur J Hum Genet. 2015 Sep;23(9):1229-35. doi: 10.1038/ejhg.2014.280. Epub 2015 Jan 14. PubMed PMID: 25585699; PubMed Central PMCID: PMC4538210.

  • Curran JE, Kumar S, Cromack DT, Hu SL, Coletta DK, Dyer TD, Arya R, Carless M, Tripathy D, Blangero J, Duggirala R, Göring HH, DeFronzo RA, Jenkinson CP. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). (2015) World Biomedical Frontiers, Diabetes and Obesity Section ISSN; published online. ISSN: 2328-0166. http://biomedfrontiers.org/diabetes-obesity-2015-9-11/

  • Winnier DA, Fourcaudot M, Norton L, Abdul-Ghani MA, Hu SL, Farook VS, Coletta DK, Kumar S, Puppala S, Chittoor G, Dyer TD, Arya R, Carless M, Lehman DM, Curran JE, Cromack DT, Tripathy D, Blangero J, Duggirala R, Göring HH, DeFronzo RA, Jenkinson CP. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). PLoS One. 2015 Apr 1;10(4):e0119941. doi: 10.1371/journal.pone.0119941.  eCollection 2015. PubMed PMID: 25830378; PubMed Central PMCID: PMC4382323.

Manuscript Review

  • PLoS One

  • International Journal of Human Genetics

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